Recombinant Human LILRB2 Protein, C-Avi-6His tagged, Biotinylated

• Cat.No.: LILRB2-30H
• Product Overview: Recombinant Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 is produced by our Mammalian expression system and the target gene encoding Gln22-His458 is expressed with a Avi, 6His tag at the C-terminus.

Specification

• Description: Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.
• Source: Human Cells
• Species: Human
• Tag: C-Avi-6His
• Protein Length: Gln22-His458
• Endotoxin: Less than 0.1 ng/μg (1 EU/μg)
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Shipping: Ambient

Gene Information

• Gene Name: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 [ Homo sapiens (human) ]
• Official Symbol: LILRB2
• Synonyms: Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2; LIR-2; Leukocyte Immunoglobulin-Like Receptor 2; CD85 Antigen-Like Family Member D; Immunoglobulin-Like Transcript 4; ILT-4; Monocyte/Macrophage Immunoglobulin-Like Receptor 10; MIR-10; CD85d; LILRB2; ILT4; LIR2; MIR10
• Gene ID: 10288
• mRNA Refseq: NM_001080978
• Protein Refseq: NP_001074447
• MIM: 604815
• UniProt ID: Q8N423