Recombinant Human LIPA Protein (22-399 aa), GST-tagged

• Cat.No.: LIPA-627H
• Product Overview: Recombinant Human LIPA Protein (22-399 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Research Area: Metabolism. Protein Description: Full Length of Mature Protein.

Specification

• Description: Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 70.0 kDa
• Protein length: 22-399 aa
• AA Sequence: SGGKLTAVDPETNMNVSEIISYWGF PSEEYLVETEDGYILCLNRIPHGRK NHSDKGPKPVVFLQHGLLADSSNWV TNLANSSLGFILADAGFDVWMGNSR GNTWSRKHKTLSVSQDEFWAFSYDE MAKYDLPASINFILNKTGQEQVYYV GHSQGTTIGFIAFSQIPELAKRIKM FFALGPVASVAFCTSPMAKLGRLPD HLIKDLFGDKEFLPQSAFLKWLGTH VCTHVILKELCGNLCFLLCGFNERN LNMSRVDVYTTHSPAGTSVQNMLHW SQAVKFQKFQAFDWGSSAKNYFHYN QSYPPTYNVKDMLVPTAVWSGGHDW LADVYDVNILLTQITNLVFHESIPE WEHLDFIWGLDAPWRLYNKIINLMR KYQ
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: LIPA lipase A, lysosomal acid, cholesterol esterase [ Homo sapiens ]
• Official Symbol: LIPA
• Synonyms: LIPA; CESD; LAL; Wolman disease; sterol esterase
• Gene ID: 3988
• mRNA Refseq: NM_000235
• Protein Refseq: NP_000226
• MIM: 613497
• UniProt ID: P38571