| Description : |
The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
93.4 kDa |
| AA Sequence : |
MNYVGQLAETVFGTVKELYRGLNPA TLSGGIDVLVVKQVDGSFRCSPFHV RFGKLGVLRSREKVVDIELNGEPVD LHMKLGDSGEAFFVQELESDDEHVP PGLCTSPIPWGGLSGFPSDSQLGTA SEPEGLVMAGTASTGRRKRRRRRKP KQKEDAVATDSSPEELEAGAESELS LPEKLRPEPPGVQLEEKSSLQPKDI YPYSDGEWPPQASLSAGELTSPKSD SELEVRTPEPSPLRAESHMQWAWGR LPKVARAERPESSVVLEGRAGATSP PRGGPSTPSTSVAGGVDPLGLPIQQ TEAGADLQPDTEDPTLVGPPLHTPE TEESKTQSSGDMGLPPASKSWSWAT LEVPVPTGQPERVSRGKGSPKRSQH LGPSDIYLDDLPSLDSENAALYFPQ SDSGLGARRWSEPSSQKSLRDPNPE HEPEPTLDTVDTIALSLCGGLADSR DISLEKFNQHSVSYQDLTKNPGLLD DPNLVVKINGKHYNWAVAAPMILSL QAFQKNLPKSTMDKLEREKMPRKGG RWWFSWRRRDFLAEERSAQKEKTAA KEQQGEKTEVLSSDDDAPDSPVILE IPSLPPSTPPSTPTYKKSLRLSSDQ IRRLNLQEGANDVVFSVTTQYQGTC RCKATIYLWKWDDKVVISDIDGTIT KSDALGHILPQLGKDWTHQGITSLY HKIQLNGYKFLYCSARAIGMADLTK GYLQWVSEGGCSLPKGPILLSPSSL FSALHREVIEKKPEVFKVACLSDIQ QLFLPHGQPFYAAFGNRPNDVFAYR QVGLPESRIFTVNPRGELIQELIKN HKSTYERLGEVVELLFPPVARGPST DLANPEYSNFCYWREPLPAVDLDTL DTRTRPLEQKLISEEDLAANDILDY KDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
