Active Recombinant Human LTBR protein, Fc-tagged
Cat.No. : | LTBR-635H |
Product Overview : | Recombinant Human LTBR(Gln31-Met225) fused with N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO. |
- Specification
- Gene Information
- Related Products
Description : | The LTβR activates two different NF-κB pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTβR activates the classical NF-κB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1β. However, LTβR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival. |
Source : | CHO |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by its binding ability in a functional ELISA. |
Molecular Mass : | 50 KDa (monomer) |
Protein length : | Gln31-Met225 |
Endotoxin : | <0.06 EU/μg as determined by LAL test. |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Storage : | Stable for at least 1 year after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Gene Name : | LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) [ Homo sapiens ] |
Official Symbol : | LTBR |
Synonyms : | LTBR; lymphotoxin beta receptor (TNFR superfamily, member 3); D12S370; tumor necrosis factor receptor superfamily member 3; TNF R III; TNFCR; TNFR RP; TNFR2 RP; TNFRSF3; TNF-RIII; TNFR-III; lymphotoxin B receptor; lymphotoxin-beta receptor; TNFR superfamily, member 3; tumor necrosis factor C receptor; tumor necrosis factor receptor type III; tumor necrosis factor receptor 2-related protein; tumor necrosis factor receptor superfamily, member 3; CD18; TNFR-RP; TNFR2-RP; LT-BETA-R; TNF-R-III; |
Gene ID : | 4055 |
mRNA Refseq : | NM_002342 |
Protein Refseq : | NP_002333 |
MIM : | 600979 |
UniProt ID : | P36941 |
Chromosome Location : | 12p13 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; |
Function : | identical protein binding; protein binding; receptor activity; |
Products Types
◆ Recombinant Protein | ||
LTBR-4589H | Recombinant Human LTBR Protein, GST-tagged | +Inquiry |
LTBR-369H | Recombinant Human LTBR Protein, Fc-tagged | +Inquiry |
LTBR-2411R | Recombinant Rhesus Macaque LTBR Protein, His (Fc)-Avi-tagged | +Inquiry |
LTBR-190H | Recombinant Human LTBR protein, Fc-tagged | +Inquiry |
LTBR-1752H | Recombinant Human LTBR Protein, His&GST-tagged | +Inquiry |
◆ Lysates | ||
LTBR-1052RCL | Recombinant Rat LTBR cell lysate | +Inquiry |
LTBR-1229CCL | Recombinant Cynomolgus LTBR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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