| Cat. No. : |
LTA-5067H |
| roduct Overview : |
Recombinant human LTAwas expressed in Hi-5 Insect cells and purified by using SDS PAGE and HPLC. |
| Description : |
LTA is a potentmediator of inflammatory and immune responses. It belongs to the TNFsuperfamily of ligands and signals through TNFR1 and TNFR2. LTA is producedby activated T and B lymphocytes, and has similar activities to TNF-alpha.Like TNF-alpha, LTA is involved in the regulation of various biologicalprocesses incuding cell proliferation, differentiation, apoptosis, lipidmetabolism, coagulation, and neurotransmission. LTA is secreted as a solublepolypeptide, but can form heterotrimers with lymphotoxin-beta, whicheffectively anchors the LTA to the cell surface. LTA is cytotoxic to a widerange of tumor cells. |
| Source : |
Human |
| Host : |
Hi-5 Insect cells |
| Form : |
Lyophilizedfrom 10mM Na3PO4, pH 7.0, with 50 mM NaCl. Reconstitute in Water to aconcentration of 0.1-1.0 mg/ml. |
| Purity : |
>98% pure by SDSPAGE and HPLC |
| Sequence : |
Region of TNF betaprotein corresponding to amino acids GVGLTPSAAQ TARQHPKMHL AHSTLKPAAHLIGDPSKQNS LLWRANTDRA FLQDGFSLSN NSLLVPTSGI YFVYSQVVFS GKAYSPKATS SPLYLAHEVQLFSSQYPFHV PLLSSQKMVY PGLQEPWLHS MYHGAAFQLT QGDQLSTHTD GIPHLVLSPS TVFFGAFAL. |
| Molecular Mass : |
18.6 kDa |
| Applications : |
Numerousapplications are possible with this product and should be tested by the enduser under their own laboratory conditions. |
| Storage : |
Storeat 4 deg C until reconstitution. Following reconstitution aliquot and freezeat -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
| OfficialSymbol : |
LTA |
