Recombinant Human MALT1 protein, His/Thioredoxin-tagged

• Cat.No.: MALT1-857H
• Product Overview: Recombinant Human MALT1((Gln 2-Ile57) fused with His/Thioredoxin tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Source: E. coli
• Species: Human
• Tag: His/Thioredoxin
• Form: Supplied as a 0.45 µm filtered solution in 50 mM NaH2PO4 (pH 7.4), 0.3 M NaCl, 80 mM imidazole, 6 M urea.
• Molecular Mass: 27 kDa (including N-terminal thioredoxin tag)
• Purity: ~0.9
• Applications: ELISA, EIA, protein-protein interaction studies, Western Blotting, Dot Blotting, Immunoprecipitation, Protein Array
• Storage: Upon arrival, the protein may be stored for 2 weeks at 4 centigrade. For long term storage, it is recommended to store at -20 centigrade or -80 centigrade in appropriate aliquots. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 [ Homo sapiens ]
• Official Symbol: MALT1
• Synonyms: MALT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; MLT; mucosa-associated lymphoid tissue lymphoma translocation protein 1; paracaspase; caspase-like protein; MALT associated translocation; MALT lymphoma-associated translocation; MALT-lymphoma associated translocation; MLT1; DKFZp434L132
• Gene ID: 10892
• mRNA Refseq: NM_006785
• Protein Refseq: NP_006776
• MIM: 604860
• UniProt ID: Q9UDY8
• Chromosome Location: 18q21
• Pathway: Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; BCR signaling pathway, organism-specific biosystem; Canonical NF-kappaB pathway, organism-specific biosystem; Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem
• Function: cysteine-type endopeptidase activity; contributes_to kinase activator activity; peptidase activity; protein binding; protein self-association; signal transducer activity; ubiquitin-protein ligase activity

Reviews

06/26/2022

From recombinant protein production to modification or labeling services, the company is committed to assisting researchers in obtaining the MALT1 protein in the format and specifications required for their particular studies.

08/19/2020

the manufacturer understands the importance of customization and can offer tailored solutions to meet specific research needs.

03/20/2020

the MALT1 protein's exceptional qualities, combined with the manufacturer's comprehensive technical support, make it an ideal choice for researchers seeking reliable experimental materials and reliable assistance in their scientific endeavors.

Q&As

Can MALT1 protein play a role in regulating immune responses in transplant patients?

MALT1 inhibitors are being investigated to prevent graft rejection and reduce the need for immunosuppressive drugs in transplant recipients.

Are there any genetic mutations or polymorphisms related to MALT1 protein that impact patient health?

Some genetic variations in MALT1 may influence susceptibility to certain diseases, including autoimmune conditions.

Are there any clinical applications for MALT1 protein in cancer research?

Yes, MALT1 is implicated in lymphoma and other hematological malignancies, making it a potential therapeutic target.

Can MALT1 protein be targeted for cancer treatment?

Yes, researchers are exploring MALT1 inhibitors as potential cancer therapeutics to block its activity in lymphomas.

How does MALT1 protein contribute to lymphocyte activation and proliferation?

MALT1 is involved in the activation of T and B cells, which are essential for the adaptive immune response.