Recombinant Human MALT1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: MALT1-2551H
• Product Overview: MALT1 MS Standard C13 and N15-labeled recombinant protein (NP_776216) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 90.9 kDa
• AA Sequence: MSLLGDPLQALPPSAAPTGPLLAPP AGATLNRLREPLLRRLSELLDQAPE GRGWRRLAELAGSRGRLRLSCLDLE QCSLKVLEPEGSPSLCLLKLMGEKG CTVTELSDFLQAMEHTEVLQLLSPP GIKITVNPESKAVLAGQFVKLCCRA TGHPFVQYQWFKMNKEIPNGNTSEL IFNAVHVKDAGFYVCRVNNNFTFEF SQWSQLDVCDIPESFQRSVDGVSES KLQICVEPTSQKLMPGSTLVLQCVA VGSPIPHYQWFKNELPLTHETKKLY MVPYVDLEHQGTYWCHVYNDRDSQD SKKVEIIIDELNNLGHPDNKEQTTD QPLAKDKVALLIGNMNYREHPKLKA PLVDVYELTNLLRQLDFKVVSLLDL TEYEMRNAVDEFLLLLDKGVYGLLY YAGHGYENFGNSFMVPVDAPNPYRS ENCLCVQNILKLMQEKETGLNVFLL DMCRKRNDYDDTIPILDALKVTANI VFGYATCQGAEAFEIQHSGLANGIF MKFLKDRLLEDKKITVLLDEVAEDM GKCHLTKGKQALEIRSSLSEKRALT DPIQGTEYSAESLVRNLQWAKAHEL PESMCLKFDCGVQIQLGFAAEFSNV MIIYTSIVYKPPEIIMCDAYVTDFP LDLDIDPKDANKGTPEETGSYLVSK DLPKHCLYTRLSSLQKLKEHLVFTV CLSYQYSGLEDTVEDKQEVNVGKPL IAKLDMHRGLGRKTCFQTCLMSNGP YQSSAATSGGAGHYHSLQDPFHGVY HSHPGNPSNVTPADSCHCSRTPDAF ISSFAHHASCHFSRSNVPVETTDEI PFSFSDRLRISEKTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 [ Homo sapiens (human) ]
• Official Symbol: MALT1
• Synonyms: MALT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; MLT; mucosa-associated lymphoid tissue lymphoma translocation protein 1; paracaspase; caspase-like protein; MALT associated translocation; MALT lymphoma-associated translocation; MALT-lymphoma associated translocation; MLT1; DKFZp434L132
• Gene ID: 10892
• mRNA Refseq: NM_173844
• Protein Refseq: NP_776216
• MIM: 604860
• UniProt ID: Q9UDY8

Reviews

06/26/2022

From recombinant protein production to modification or labeling services, the company is committed to assisting researchers in obtaining the MALT1 protein in the format and specifications required for their particular studies.

08/19/2020

the manufacturer understands the importance of customization and can offer tailored solutions to meet specific research needs.

03/20/2020

the MALT1 protein's exceptional qualities, combined with the manufacturer's comprehensive technical support, make it an ideal choice for researchers seeking reliable experimental materials and reliable assistance in their scientific endeavors.

Q&As

Can MALT1 protein play a role in regulating immune responses in transplant patients?

MALT1 inhibitors are being investigated to prevent graft rejection and reduce the need for immunosuppressive drugs in transplant recipients.

Are there any genetic mutations or polymorphisms related to MALT1 protein that impact patient health?

Some genetic variations in MALT1 may influence susceptibility to certain diseases, including autoimmune conditions.

Are there any clinical applications for MALT1 protein in cancer research?

Yes, MALT1 is implicated in lymphoma and other hematological malignancies, making it a potential therapeutic target.

Can MALT1 protein be targeted for cancer treatment?

Yes, researchers are exploring MALT1 inhibitors as potential cancer therapeutics to block its activity in lymphomas.

How does MALT1 protein contribute to lymphocyte activation and proliferation?

MALT1 is involved in the activation of T and B cells, which are essential for the adaptive immune response.