Recombinant Human MAX protein, His & GST-tagged

• Cat.No.: MAX-1547H
• Product Overview: Recombinant Human MAX aa. (Ser2~Ser160 (Accession # P61244)) fused with N-terminal His & GST tag was produced in E. coli cells.

Specification

• Description: The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: His & GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 48.1kDa
• Protein length: Ser2~Ser160 (Accession # P61244)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Isoelectric Point: 5.9

Gene Information

• Gene Name: MAX MYC associated factor X [ Homo sapiens (human) ]
• Official Symbol: MAX
• Synonyms: MAX; MYC associated factor X; bHLHd4; protein max; class D basic helix-loop-helix protein 4
• Gene ID: 4149
• mRNA Refseq: NM_001271068.1
• Protein Refseq: NP_001257997.1
• UniProt ID: P61244

Reviews

07/16/2023

Greatly improve the rate and selectivity of chemical reactions, and its scientific research value is incomparable.

05/14/2023

MAX has excellent labeling results and can be used for a wide range of experimental methods, such as fluorescent labeling.

06/11/2021

The high catalytic efficiency, high safety, and high expression level make the experimental results extremely confident.

Q&As

How to evaluate the potential of MAX proteins as drug targets?

Evaluating the potential of MAX proteins as drug targets can involve several aspects, including their expression levels in organisms, their role in biological processes, and their changes in disease. In addition, factors such as ease of drug development for this protein and potential drug side effects need to be considered.

What is the function of MAX proteins?

The function of MAX proteins may be related to their localization and structure within the cell. It may be a nuclear protein that regulates the transcription of specific genes by binding to DNA. In addition, it may also regulate processes such as cell signaling and cell proliferation by interacting with other proteins.

What are the effects of mutations or modifications in MAX proteins on organisms?

Mutations or modifications of MAX proteins may affect their function and thus on the organism. The specific effects may vary depending on the type and location of the mutation or modification and may involve various biological processes, such as growth and development, immune response, etc.

What biological processes does MAX protein play a role in?

MAX proteins may be involved in a variety of biological processes, including cell proliferation, cell differentiation, apoptosis, etc. It may influence tumorigenesis and progression by modulating these processes.

How is the expression level of MAX protein regulated?

The expression level of MAX protein may be regulated by a variety of factors, including gene transcription, translation, post-transcriptional modification, etc. Studying these regulatory mechanisms can help to understand the expression patterns of MAX proteins in organisms and their effects on biological processes.

How does MAX protein interact with other proteins?

MAX proteins may interact with other proteins to fulfill their functions. These interactions can involve various types of protein-protein interactions like electrostatic interactions, hydrogen bonding, etc. Understanding these interactions can help uncover the mechanism of action of MAX proteins in cells.