Recombinant Human MB21D1 Protein (161-522 aa), His-SUMO-tagged
Cat.No. : | MB21D1-2114H |
Product Overview : | Recombinant Human MB21D1 Protein (161-522 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Protein Description: Partial. |
- Specification
- Gene Information
- Related Products
Description : | Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115). |
Source : | E. coli |
Species : | Human |
Tag : | His-SUMO |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 58.3 kDa |
Protein length : | 161-522 aa |
AA Sequence : | GASKLRAVLEKLKLSRDDISTAAGM VKGVVDHLLLRLKCDSAFRGVGLLN TGSYYEHVKISAPNEFDVMFKLEVP RIQLEEYSNTRAYYFVKFKRNPKEN PLSQFLEGEILSASKMLSKFRKIIK EEINDIKDTDVIMKRKRGGSPAVTL LISEKISVDITLALESKSSWPASTQ EGLRIQNWLSAKVRKQLRLKPFYLV PKHAKEGNGFQEETWRLSFSHIEKE ILNNHGKSKTCCENKEEKCCRKDCL KLMKYLLEQLKERFKDKKHLDKFSS YHVKTAFFHVCTQNPQDSQWDRKDL GLCFDNCVTYFLQCLRTEKLENYFI PEFNLFSSNLIDKRSKEFLTKQIEY ERNNEFPVFDEF |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with reconstitution instruction is sent along with the products. |
Gene Name : | MB21D1 Mab-21 domain containing 1 [ Homo sapiens ] |
Official Symbol : | MB21D1 |
Synonyms : | MB21D1; protein MB21D1; C6orf150; MGC131892; MGC142166; MGC142168; |
Gene ID : | 115004 |
mRNA Refseq : | NM_138441 |
Protein Refseq : | NP_612450 |
MIM : | 613973 |
UniProt ID : | Q8N884 |
Products Types
◆ Recombinant Protein | ||
MB21D1-5392M | Recombinant Mouse MB21D1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MB21D1-9597M | Recombinant Mouse MB21D1 Protein | +Inquiry |
Mb21d1-1625M | Recombinant Mouse Mb21d1 protein, His & T7-tagged | +Inquiry |
◆ Lysates | ||
MB21D1-7994HCL | Recombinant Human C6orf150 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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