Recombinant Human Mesothelin

• Cat.No.: MSLN-01H
• Product Overview: A DNA sequence encoding the human MSLN (H3BUX1) (Met1-Thr398) was expressed in HEK293.

Specification

• Source: HEK293
• Species: Human
• Form: Lyophilized from 50 mM Tris-HCl, pH 7.4, 100mM NaCl, and 5% Trehalose
• Molecular Mass: 43.8 kDa
• Purity: >98% as determined by SDS-PAGE
• Storage: This lyophilized preparation is stable at 4°C, but should be kept at -20°C for long term storage. Upon reconstitution, the preparation is stable for up to 2 weeks at 4°C. For maximal stability, apportion the reconstituted preparation into sterile distilled water or working aliquots with 20% glycerol or 0.1% BSA and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
• Reconstitution: It is recommended to reconstitute the lyophilized MSLN in 0.1ml sterile and pre-cooled ddH2O, which can then be further diluted to other aqueous solutions.

Gene Information

• Gene Name: MSLN mesothelin [ Homo sapiens ]
• Official Symbol: MSLN
• Synonyms: MSLN; mesothelin; CAK1; MPF; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor; SMRP
• Gene ID: 10232
• mRNA Refseq: NM_001177355
• Protein Refseq: NP_001170826
• MIM: 601051
• UniProt ID: Q13421
• Chromosome Location: 16p13.3

Reviews

05/22/2022

Very satisfied, great product.

03/06/2022

Product is high-quality.

09/30/2021

Excellent for experiments, reliable.

Q&As

What is the primary role of MSLN in normal tissues?

MSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.

How is MSLN expression altered in cancerous cells?

In cancer, MSLN expression is significantly upregulated.

In which types of cancer is MSLN overexpressed?

MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.

Are there any therapeutic strategies targeting MSLN in cancer treatment?

Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.

How can MSLN levels be detected and measured in clinical settings?

MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.

What is the prognostic significance of MSLN overexpression in cancer patients?

MSLN overexpression is often associated with poor prognosis in cancer patients.

How does MSLN contribute to cancer progression and metastasis?

MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.