| Description : |
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
155.54 kDa |
| AA Sequence : |
MKAPAVLAPGILVLLFTLVQRSNGE CKEALAKSEMNVNMKYQLPNFTAET PIQNVILHEHHIFLGATNYIYVLNE EDLQKVAEYKTGPVLEHPDCFPCQD CSSKANLSGGVWKDNINMALVVDTY YDDQLISCGSVNRGTCQRHVFPHNH TADIQSEVHCIFSPQIEEPSQCPDC VVSALGAKVLSSVKDRFINFFVGNT INSSYFPDHPLHSISVRRLKETKDG FMFLTDQSYIDVLPEFRDSYPIKYV HAFESNNFIYFLTVQRETLDAQTFH TRIIRFCSINSGLHSYMEMPLECIL TEKRKKRSTKKEVFNILQAAYVSKP GAQLARQIGASLNDDILFGVFAQSK PDSAEPMDRSAMCAFPIKYVNDFFN KIVNKNNVRCLQHFYGPNHEHCFNR TLLRNSSGCEARRDEYRTEFTTALQ RVDLFMGQFSEVLLTSISTFIKGDL TIANLGTSEGRFMQVVVSRSGPSTP HVNFLLDSHPVSPEVIVEHTLNQNG YTLVITGKKITKIPLNGLGCRHFQS CSQCLSAPPFVQCGWCHDKCVRSEE CLSGTWTQQICLPAIYKVFPNSAPL EGGTRLTICGWDFGFRRNNKFDLKK TRVLLGNESCTLTLSESTMNTLKCT VGPAMNKHFNMSIIISNGHGTTQYS TFSYVDPVITSISPKYGPMAGGTLL TLTGNYLNSGNSRHISIGGKTCTLK SVSNSILECYTPAQTISTEFAVKLK IDLANRETSIFSYREDPIVYEIHPT KSFISGGSTITGVGKNLNSVSVPRM VINVHEAGRNFTVACQHRSNSEIIC CTTPSLQQLNLQLPLKTKAFFMLDG ILSKYFDLIYVHNPVFKPFEKPVMI SMGNENVLEIKGNDIDPEAVKGEVL KVGNKSCENIHLHSEAVLCTVPNDL LKLNSELNIEWKQAISSTVLGKVIV QPDQNFTGLIAGVVSISTALLLLLG FFLWLKKRKQIKDLGSELVRYDARV HTPHLDRLVSARSVSPTTEMVSNES VDYRATFPEDQFPNSSQNGSCRQVQ YPLTDMSPILTSGDSDISSPLLQNT VHIDLSALNPELVQAVQHVVIGPSS LIVHFNEVIGRGHFGCVYHGTLLDN DGKKIHCAVKSLNRITDIGEVSQFL TEGIIMKDFSHPNVLSLLGICLRSE GSPLVVLPYMKHGDLRNFIRNETHN PTVKDLIGFGLQVAKGMKYLASKKF VHRDLAARNCMLDEKFTVKVADFGL ARDMYDKEYYSVHNKTGAKLPVKWM ALESLQTQKFTTKSDVWSFGVLLWE LMTRGAPPYPDVNTFDITVYLLQGR RLLQPEYCPDPLYEVMLKCWHPKAE MRPSFSELVSRISAIFSTFIGEHYV HVNATYVNVKCVAPYPSLLSSEDNA DDEVDTRPASFWETSTRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
