Recombinant Human MGMT Protein, GST-tagged
Cat.No. : | MGMT-5304H |
Product Overview : | Human MGMT full-length ORF ( AAH00824, 1 a.a. - 207 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 48.4 kDa |
AA Sequence : | MDKDCEMKRTTLDSPLGKLELSGCE QGLHEIKLLGKGTSAADAVEVPAPA AVLGGPEPLMQCTAWLNAYFHQPEA IEEFPVPALHHPVFQQESFTRQVLW KLLKVVKFGEVISYQQLAALAGNPK AARAVGGAMRGNPVPILIPCHRVVC SSGAVGNYSGGLAVKEWLLAHEGHR LGKPGLGGSSGLAGAWLKGAGATSG SPPAGRN |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | MGMT O-6-methylguanine-DNA methyltransferase [ Homo sapiens ] |
Official Symbol : | MGMT |
Synonyms : | MGMT; O-6-methylguanine-DNA methyltransferase; methylated-DNA--protein-cysteine methyltransferase; methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase; O6-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase; |
Gene ID : | 4255 |
mRNA Refseq : | NM_002412 |
Protein Refseq : | NP_002403 |
MIM : | 156569 |
UniProt ID : | P16455 |
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◆ Lysates | ||
MGMT-1109HCL | Recombinant Human MGMT cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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