"MLLT3" Related Products

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Recombinant Human MLLT3 protein, GST-tagged

Cat.No.: MLLT3-266H
Product Overview: Recombinant Human MLLT3(1-149 aa)(YEATS DOMAIN, F78A) fused with GST tag at N-terminal was expressed in E. coli.
Description: The AF9 protein is part of the super elongation complex and also associates with the histone methyltransferase DOT1L. Translocation of the AF9 gene to the MLL gene, resulting in an MLL/AF9 fusion is the most common chromosomal rearrangement involving MLL in de novo AML. The YEATS domain of binds strongly to histone H3K9 acetylation and, to a lesser extent, H3K27 and H3K18 acetylation. AF9 YEATS Domain, F78A, Recombinant Human contains a phenylalanine to alanine substitution at position 78.
Source: E. coli
Species: Human
Tag : GST
Form: Recombinant protein at 1 mg/ml in 20 mM Tris-HCl pH 7.5, 150 mM NaCl, 1mM EDTA, 1 mM DTT, 20% glycerol.
Molecular Mass: 41 kDa
Applications: AF9 YEATS Domain, F78A, Recombinant Human is useful for protein binding and screening experiments using AF9 YEATS Domain, Recombinant Human to examine acetylated protein substrates.
Storage: Stable for six months at -80 centigrade from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.
Concentration: 1 mg/ml
Gene Name: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 [ Homo sapiens ]
Official Symbol: MLLT3
Synonyms: MLLT3; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3; myeloid/lymphoid or mixed lineage leukemia (trithorax (Drosophila) homolog); translocated to, 3; protein AF-9; AF 9; AF9; YEATS3; YEATS domain-containing protein 3; ALL1-fused gene from chromosome 9 protein; myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3; FLJ2035;
Gene ID: 4300
mRNA Refseq: NM_004529
Protein Refseq: NP_004520
MIM: 159558
UniProt ID: P42568
Chromosome Location: 9p22
Pathway: Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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