| Description : |
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
52.7 kDa |
| AA Sequence : |
MHSFPPLLLLLFWGVVSHSFPATLE TQEQDVDLVQKYLEKYYNLKNDGRQ VEKRRNSGPVVEKLKQMQEFFGLKV TGKPDAETLKVMKQPRCGVPDVAQF VLTEGNPRWEQTHLTYRIENYTPDL PRADVDHAIEKAFQLWSNVTPLTFT KVSEGQADIMISFVRGDHRDNSPFD GPGGNLAHAFQPGPGIGGDAHFDED ERWTNNFREYNLHRVAAHELGHSLG LSHSTDIGALMYPSYTFSGDVQLAQ DDIDGIQAIYGRSQNPVQPIGPQTP KACDSKLTFDAITTIRGEVMFFKDR FYMRTNPFYPEVELNFISVFWPQLP NGLEAAYEFADRDEVRFFKGNKYWA VQGQNVLHGYPKDIYSSFGFPRTVK HIDAALSEENTGKTYFFVANKYWRY DEYKRSMDPGYPKMIAHDFPGIGHK VDAVFMKDGFFYFFHGTRQYKFDPK TKRILTLQKANSWFNCRKN |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
