| Description : |
This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
52.3 kDa |
| AA Sequence : |
MTLKASEGESGGSMHTALSDLYLEH LLQKRSRPEAVSHPLNTVTEDMYTN GSPAPGSPAQVKGQEVRKVRLIQFE KVTEEPMGITLKLNEKQSCTVARIL HGGMIHRQGSLHVGDEILEINGTNV TNHSVDQLQKAMKETKGMISLKVIP NQQSRLPALQMFMRAQFDYDPKKDN LIPCKEAGLKFATGDIIQIINKDDS NWWQGRVEGSSKESAGLIPSPELQE WRVASMAQSAPSEAPSCSPFGKKKK YKDKYLAKHSSIFDQLDVVSYEEVV RLPAFKRKTLVLIGASGVGRSHIKN ALLSQNPEKFVYPVPYTTRPPRKSE EDGKEYHFISTEEMTRNISANEFLE FGSYQGNMFGTKFETVHQIHKQNKI AILDIEPQTLKIVRTAELSPFIVFI APTDQGTQTEALQQLQKDSEAIRSQ YAHYFDLSLVNNGVDETLKKLQEAF DQACSSPQWVPVSWVYTRTRPLEQK LISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
