| Description : |
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
97.7 kDa |
| AA Sequence : |
MGMDLTCPFGVSPACGAQASWSIFG ADAAEVPGTRGHSQQEAAMPHIPED EEPPGEPQAAQSPAGQGPPTAGVSC SPTPTIVLTGDATSPEGETDKNLAN RVHSPHKRLSHRHLKVSTASLTSVD PAGHIIDLVNDQLPDISISEEDKKK NLALLEEAKLVSERFLTRRGRKSRS SPGDSPSAVSPNLSPSASPTSSRSN SLTVPTPPGLDVCSGPPSPLPGAPP QKGDEADVSSPHPGEPNVPKGLADR KQNDQRKVSQGRLAPRPPPVEKSKE IAIEQKENFDPLQYPETTPKGLAPV TNSSGKMALNSPQPGPVESELGKQL LKTGWEGSPLPRSPTQDAAGVGPPA SQGRGPAGEPMGPEAGSKAELPPTV SRPPLLRGLSWDSGPEEPGPRLQKV LAKLPLAEEEKRFAGKAGGKLAKAP GLKDFQIQVQPVRMQKLTKLREEHI LMRNQNLVGLKLPDLSEAAEQEKGL PSELSPAIEEEESKSGLDVMPNISD VLLRKLRVHRSLPGSAPPLTEKEVE NVFVQLSLAFRNDSYTLESRINQAE RERNLTEENTEKELENFKASITSSA SLWHHCEHRETYQKLLEDIAVLHRL AARLSSRAEVVGAVRQEKRMSKATE VMMQYVENLKRTYEKDHAELMEFKK LANQNSSRSCGPSEDGVPRTARSMS LTLGKNMPRRRVSVAVVPKFNALNL PGQTPSSSSIPSLPALSESPNGKGS LPVTSALPALLENGKTNGDPDCEAS APALTLSCLEELSQETKARMEEEAY SKGFQEGLKKTKELQDLKEEEEEQK SESPEEPEEVEETEEEEKGPRSSKL EELVHFLQVMYPKLCQHWQVIWMMA AVMLVLTVVLGLYNSYNSCAEQADG PLGRSTCSAAQRDSWWSSGLQHEQP TEQTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
