Recombinant Human MSLN Protein, hFc-tagged

• Cat.No.: MSLN-75H
• Product Overview: Recombinant Human MSLN Protein, fused to hFc-tag, was expressed in HEK293.

Specification

• Description: This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
• Source: HEK293
• Species: Human
• Tag: hFc
• Form: Supplied as a 0.2 μm filtered solution in PBS , pH7.4.
• Molecular Mass: 61.96 kDa
• AA Sequence: MHSSALLCCLVLLTGVRAEVEKTAC PSGKKAREIDESLIFYKKWELEACV DAALLATQMDRVNAIPFTYEQLDVL KHKLDELYPQGYPESVIQHLGYLFL KMSPEDIRKWNVTSLETLKALLEVN KGHEMSPQVATLIDRFVKGRGQLDK DTLDTLTAFYPGYLCSLSPEELSSV PPSSIWAVRPQDLDTCDPRQLDVLY PKARLAFQNMNGSEYFVKIQSFLGG APTEDLKALSQQNVSMDLATFMKLR TDAVLPLTVAEVQKLLGPHVEGLKA EERHRPVRDWILRQRQDDLDTLGLG LQGGIPNGYLVLDLSTTENLYFQGS TGTHTCPPCPAPELLGGPSVFLFPP KPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPREEQ YNSTYRVVSVLTVLHQDWLNGKEYK CKVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSREEMTKNQVSLTCLVK GFYPSDIAVEWESNGQPENNYKTTP PVLDSDGSFFLYSKLTVDKSRWQQG NVFSCSVMHEALHNHYTQKSLSLSP GK
• Purity: >90%
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 0.86 mg/ml

Gene Information

• Gene Name: MSLN mesothelin [ Homo sapiens (human) ]
• Official Symbol: MSLN
• Synonyms: MPF; SMRP
• Gene ID: 10232
• mRNA Refseq: NM_005823
• Protein Refseq: NP_005814
• MIM: 601051
• UniProt ID: Q13421

Reviews

05/22/2022

Very satisfied, great product.

03/06/2022

Product is high-quality.

09/30/2021

Excellent for experiments, reliable.

Q&As

What is the primary role of MSLN in normal tissues?

MSLN is normally expressed in mesothelial cells, playing a role in cell adhesion.

How is MSLN expression altered in cancerous cells?

In cancer, MSLN expression is significantly upregulated.

In which types of cancer is MSLN overexpressed?

MSLN is overexpressed in mesothelioma, ovarian, and pancreatic cancers.

Are there any therapeutic strategies targeting MSLN in cancer treatment?

Therapies targeting MSLN include antibody-drug conjugates and CAR-T cell therapies.

How can MSLN levels be detected and measured in clinical settings?

MSLN levels can be assessed through immunohistochemistry and serum biomarker tests.

What is the prognostic significance of MSLN overexpression in cancer patients?

MSLN overexpression is often associated with poor prognosis in cancer patients.

How does MSLN contribute to cancer progression and metastasis?

MSLN promotes tumor cell proliferation, invasion, and resistance to apoptosis.