Recombinant Human MSR1 Protein, GST-tagged
Cat.No. : | MSR1-5664H |
Product Overview : | Human MSR1 partial ORF ( NP_619729, 121 a.a. - 220 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimers disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 36.74 kDa |
AA Sequence : | MEKRIQHILDMEANLMDTEHFQNFS MTTDQRFNDILLQLSTLFSSVQGHG NAIDEISKSLISLNTTLLDLQLNIE NLNGKIQENTFKQQEEISKLKERVY |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | MSR1 macrophage scavenger receptor 1 [ Homo sapiens ] |
Official Symbol : | MSR1 |
Synonyms : | MSR1; macrophage scavenger receptor 1; macrophage scavenger receptor types I and II; CD204; SCARA1; scavenger receptor class A member 1; scavenger receptor class A, member 1; macrophage scavenger receptor type III; macrophage acetylated LDL receptor I and II; SRA; SR-A; phSR1; phSR2; |
Gene ID : | 4481 |
mRNA Refseq : | NM_138716 |
Protein Refseq : | NP_619730 |
MIM : | 153622 |
UniProt ID : | P21757 |
Products Types
◆ Recombinant Protein | ||
Msr1-5750M | Recombinant Mouse Msr1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MSR1-103H | Recombinant Human MSR1 Protein, His-tagged | +Inquiry |
MSR1-2090H | Recombinant Human MSR1 Protein, MYC/DDK-tagged | +Inquiry |
MSR1-1793H | Recombinant Human MSR1 Protein, His&GST-tagged | +Inquiry |
MSR1-01H | Active Recombinant Human MSR1 Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
MSR1-2288MCL | Recombinant Mouse MSR1 cell lysate | +Inquiry |
MSR1-2844HCL | Recombinant Human MSR1 cell lysate | +Inquiry |
MSR1-800RCL | Recombinant Rat MSR1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket