| Description : |
Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,5-bisphosphate (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns3P), phosphatidylinositol 4-phosphate (PtdIns4P), and phosphatidylinositol 5-phosphate (PtdIns5P), phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4+ T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
71.8 kDa |
| AA Sequence : |
MEHIRTTKVEQVKLLDRFSTSNKSL TGTLYLTATHLLFIDSHQKETWILH HHIASVEKLALTTSGCPLVIQCKNF RTVHFIVPRERDCHDIYNSLLQLSK QAKYEDLYAFSYNPKQNDSERLQGW QLIDLAEEYKRMGVPNSHWQLSDAN RDYKICETYPRELYVPRIASKPIIV GSSKFRSKGRFPVLSYYHQDKEAAI CRCSQPLSGFSARCLEDEHLLQAIS KANPVNRYMYVMDTRPKLNAMANRA AGKGYENEDNYSNIRFQFVGIENIH VMRSSLQKLLEVNGTKGLSVNDFYS GLESSGWLRHIKAVMDAAVFLAKAI TVENASVLVHCSDGWDRTSQVCSLG SLLLDSYYRTIKGFMVLIEKDWISF GHKFSERCGQLDGDPKEVSPVFTQF LECVWHLTEQFPQAFEFSEAFLLQI HEHIHSCQFGNFLGNCQKEREELKL KEKTYSLWPFLLEDQKKYLNPLYSS ESHRFTVLEPNTVSFNFKFWRNMYH QFDRTLHPRQSVFNIIMNMNEQNKQ LEKDIKDLESKIKQRKNKQTDGILT KELLHSVHPESPNLKTSLCFKEQTL LPVNDALRTIEGSSPADNRYSEYAE EFSKSEPAVVSLEYGVARMTCTRTR PLEQKLISEEDLAANDILDYKDDDD KV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
