Recombinant Human MUC16 Protein, Fc\Avi-tagged

• Cat.No.: MUC16-200H
• Product Overview: Biotinylated Recombinant Human Mucin-16 is produced by our Mammalian expression system and thetarget gene encoding Gly12660-Met12923 is expressed with a Fc, Avi tag at the C-terminus.

Specification

• Description: MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by tumor cells including ovarian and mesothelial cancers. The transmembrane form can adhere to mesothelin in the peritoneum, facilitating metastasis of ovarian cancer to the peritoneal cavity. MUC16 also binds galectin-1 on immune cells and enhances its expression on tumor cells. MUC16-expressing tumors adhere to NK cells, down-regulate CD16 and suppress NK response, which may promote immune evasion. MUC16 is also cyclically expressed in the endometrium and may contribute to immune privilege during pregnancy. In the eye, MUC16 and other mucins protect the cornea and keep it hydrated. It is altered on the conjunctival epithelium of patients with non-Sjogren dry eye syndrome.
• Source: Human Cells
• Species: Human
• Tag: Fc\Avi
• Form: Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.5.
• AA Sequence: Gly12660-Met12923
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Shipping: Ambient

Gene Information

• Gene Name: MUC16 mucin 16, cell surface associated [ Homo sapiens (human) ]
• Official Symbol: MUC16
• Synonyms: CA125 ovarian cancer antigen; CA125; CA-125; CA125MUC-16; FLJ14303; mucin 16, cell surface associated; mucin-16
• Gene ID: 94025
• mRNA Refseq: NM_001401501.2
• Protein Refseq: NP_001388430.1
• MIM: 606154
• UniProt ID: Q8WXI7

Reviews

07/28/2020

Critical for decision-making. Supports our research endeavors.

05/24/2018

Expert service quality. Valuable for research integrity.

06/05/2017

Dependable partner in experiments. Consistent and trustworthy.

Q&As

How does MUC16 interact with other components of the epithelial barrier and immune system?

MUC16 works with other mucins and immune components to maintain epithelial barrier function and immune responses.

How does MUC16 contribute to the formation of the mucosal barrier?

It aids in forming the mucosal barrier, protecting against pathogens and mechanical damage.

What potential therapeutic applications arise from targeting MUC16 in cancer treatment?

Targeting MUC16 in cancer therapy, especially in ovarian cancer, could be effective in inhibiting tumor growth and spread.

What is the impact of altered MUC16 activity on inflammatory and infectious diseases?

Altered MUC16 activity can impact the body's defense against inflammation and infection.

What is the primary role of MUC16 in epithelial cell function?

MUC16, a mucin protein, is essential for maintaining the protective mucous layer on epithelial surfaces.

What role does MUC16 play in cancer, particularly ovarian cancer?

MUC16 is associated with cancer progression, particularly in ovarian cancer, where it may facilitate tumor growth and metastasis.

How do genetic variations in MUC16 affect its function in mucosal protection and cancer development?

Genetic variations in MUC16 can lead to differences in mucosal integrity and potentially influence cancer susceptibility.