Recombinant Human MUC16 Protein, His-tagged
Cat.No. : | MUC16-02H |
Product Overview : | Recombinant Human MUC16 Protein(NP_078966.2), fused to His-tag, was expressed in HEK293. |
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Description : | This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | PBS, pH 7.4. |
Molecular Mass : | The protein has a calculated MW of 75 kDa. |
AA Sequence : | MEKIPVSAFLLLVALSYTLAPGSRK FNTTERVLQGLLRPLFKNTSVGPLY SGCRLTLLRPEKDGEATGVDAICTH RPDPTGPGLDREQLYLELSQLTHSI TELGPYTLDRDSLYVNGFTHRSSVP TTSTGVVSEEPFTLNFTINNLRYMA DMGQPGSLKFNITDNVMQHLLSPLF QRSSLGARYTGCRVIALRSVKNGAE TRVDLLCTYLQPLSGPGLPIKQVFH ELSQQTHGITRLGPYSLDKDSLYLN GYNEPGPDEPPTTPKPATTFLPPLS EATTAMGYHLKTLTLNFTISNLQYS PDMGKGSATFNSTEGVLQHLLRPLF QKSSMGPFYLGCQLISLRPEKDGAA TGVDTTCTYHPDPVGPGLDIQQLYW ELSQLTHGVTQLGFYVLDRDSLFIN GYAPQNLSIRGEYQINFHIVNWNLS NPDPTSSEYITLLRDIQDKVTTLYK GSQLHDTFRFCLVTNLTMDSVLVTV KALFSSNLDPSLVEQVFLDKTLNAS FHWLGSTYQLVDIHVTEMESSVYQP TSSSSTQHFYLNFTITNLPYSQDKA QPGTTNYQRNKRNIEDALNQLFRNS SIKSYFSDCQVSTFRSVPNRHHTGV DSLCNFSPLARRVDRVAIYEEFLRM TRNGTQLQNFTLDRSSVLVDGYSPN RNEPLTGNSDLPHHHHHH |
Purity : | >90%, by SDS-PAGE |
Storage : | Store it under sterile conditions at -20 to -80 ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Concentration : | 0.1 mg/ml |
Gene Name : | MUC16 mucin 16, cell surface associated [ Homo sapiens (human) ] |
Official Symbol : | MUC16 |
Synonyms : | CA125 |
Gene ID : | 94025 |
mRNA Refseq : | NM_024690.2 |
Protein Refseq : | NP_078966.2 |
MIM : | 606154 |
UniProt ID : | Q8WXI7 |
Products Types
◆ Recombinant Protein | ||
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MUC16-5748H | Recombinant Human MUC16 Protein, GST-tagged | +Inquiry |
MUC16-01H | Recombinant Human MUC16 Protein, His tagged | +Inquiry |
MUC16-28H | Recombinant Human MUC16 Protein, C-Fc-Avi tagged, Biotinylated | +Inquiry |
MUC16-42H | Active Recombinant Human MUC16 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
MUC16-1H | Native Human MUC16 protein | +Inquiry |
CDA002 | Active Native Human MUC16 Protein | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionMUC16 works with other mucins and immune components to maintain epithelial barrier function and immune responses.
It aids in forming the mucosal barrier, protecting against pathogens and mechanical damage.
Targeting MUC16 in cancer therapy, especially in ovarian cancer, could be effective in inhibiting tumor growth and spread.
Altered MUC16 activity can impact the body's defense against inflammation and infection.
MUC16, a mucin protein, is essential for maintaining the protective mucous layer on epithelial surfaces.
MUC16 is associated with cancer progression, particularly in ovarian cancer, where it may facilitate tumor growth and metastasis.
Genetic variations in MUC16 can lead to differences in mucosal integrity and potentially influence cancer susceptibility.
Customer Reviews (3)
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Dependable partner in experiments. Consistent and trustworthy.
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