Recombinant Human MUSK

• Cat.No.: MUSK-30261TH
• Product Overview: Recombinant fragment from human MUSK, cytoplasmic domain, amino acids 519-end.Expressed by baculovirus in Sf9 insect cells using an N-terminal tag, 63kDa.

Specification

• Description: This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.
• Biological activity: Specific activity is6.7 nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family.Contains 1 FZ (frizzled) domain.Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.

Gene Information

• Gene Name: MUSK muscle, skeletal, receptor tyrosine kinase [ Homo sapiens ]
• Official Symbol: MUSK
• Synonyms: MUSK; muscle, skeletal, receptor tyrosine kinase; muscle, skeletal receptor tyrosine-protein kinase
• Gene ID: 4593
• mRNA Refseq: NM_001166280
• Protein Refseq: NP_001159752
• MIM: 601296
• Uniprot ID: O15146
• Chromosome Location: 9q31.3-q32
• Function: ATP binding; PDZ domain binding; nucleotide binding; receptor activity; transmembrane receptor protein tyrosine kinase activity