| Description : |
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
140.8 kDa |
| AA Sequence : |
MPEPGKKPVSAFSKKPRSVEVAAGS PAVFEAETERAGVKVRWQRGGSDIS ASNKYGLATEGTRHTLTVREVGPAD QGSYAVIAGSSKVKFDLKVIEAEKA EPMLAPAPAPAEATGAPGEAPAPAA ELGESAPSPKGSSSAALNGPTPGAP DDPIGLFVMRPQDGEVTVGGSITFS ARVAGASLLKPPVVKWFKGKWVDLS SKVGQHLQLHDSYDRASKVYLFELH ITDAQPAFTGSYRCEVSTKDKFDCS NFNLTVHEAMGTGDLDLLSAFRRTS LAGGGRRISDSHEDTGILDFSSLLK KRDSFRTPRDSKLEAPAEEDVWEIL RQAPPSEYERIAFQYGVTDLRGMLK RLKGMRRDEKKSTAFQKKLEPAYQV SKGHKIRLTVELADHDAEVKWLKNG QEIQMSGSKYIFESIGAKRTLTISQ CSLADDAAYQCVVGGEKCSTELFVK EPPVLITRPLEDQLVMVGQRVEFEC EVSEEGAQVKWLKDGVELTREETFK YRFKKDGQRHHLIINEAMLEDAGHY ALCTSGGQALAELIVQEKKLEVYQS IADLMVGAKDQAVFKCEVSDENVRG VWLKNGKELVPDSRIKVSHIGRVHK LTIDDVTPADEADYSFVPEGFACNL SAKLHFMEVKIDFVPRQEPPKIHLD CPGRIPDTIVVVAGNKLRLDVPISG DPAPTVIWQKAITQGNKAPARPAPD APEDTGDSDEWVFDKKLLCETEGRV RVETTKDRSIFTVEGAEKEDEGVYT VTVKNPVGEDQVNLTVKVIDVPDAP AAPKISNVGEDSCTVQWEPPAYDGG QPILGYILERKKKKSYRWMRLNFDL IQELSHEARRMIEGVVYEMRVYAVN AIGMSRPSPASQPFMPIGPPSEPTH LAVEDVSDTTVSLKWRPPERVGAGG LDGYSVEYCPEGCSEWVAALQGLTE HTSILVKDLPTGARLLFRVRAHNMA GPGAPVTTTEPVTVQEILQRPRLQL PRHLRQTIQKKVGEPVNLLIPFQGK PRPQVTWTKEGQPLAGEEVSIRNSP TDTILFIRAARRVHSGTYQVTVRIE NMEDKATLVLQVVDKPSPPQDLRVT DAWGLNVALEWKPPQDVGNTELWGY TVQKADKKTMEWFTVLEHYRRTHCV VPELIIGNGYYFRVFSQNMVGFSDR AATTKEPVFIPRPGITYEPPNYKAL DFSEAPSFTQPLVNRSVIAGYTAML CCAVRGSPKPKISWFKNGLDLGEDA RFRMFSKQGVLTLEIRKPCPFDGGI YVCRATNLQGEARCECRLEVRVPQT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
