Recombinant Human Myeloperoxidase

• Cat.No.: MPO-54H
• Product Overview: Recombinant Human Myeloperoxidase protein encoding amino acids 621-745 expressed inE.coli. The MPO purified by proprietary chromatographic techniques.

Specification

• Cat. No.: MPO-54H
• Description: Myeloperoxidase is an important enzyme used by granulocytes during phagocytic lysis of foreign particles engulfed. In normal tissues and in a variety of myeloproliferative disorders myeloid cells of both neutrophilic and eosinophilic types, at all stages of maturation, exhibit strong cytoplasmic reactivity for MPO. Erythroid precursors, megakaryocytes, lymphoid cells, mast cells, and plasma cells are nonreactive. MPO is not observed in the neoplastic cells of a wide variety of epithelial tumors and sarcomas. MPO is useful in differentiating between myeloid and lymphoid leukemias.
• Source: Escherichia Coli.
• Physical Appearance: Sterile liquid clear solution.
• Formulation: The protein at 100 µg/ml in 50mM Tris-Acetate, pH 7.5, 1mM EDTA and 20% Glycerol.
• Applications: ELISA • Inhibition Assays • Western Blotting.
• Stability: Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Avoid multiple freeze-thaw cycles.

Gene Information

• Gene Name: MPO myeloperoxidase [ Homo sapiens ]
• Synonyms: MPO; myeloperoxidase; Myeloperoxidase;89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain; EC 1.11.1.7; HGNC: 7218; Entrez Gene: 4353; UniProtKB: P05164; Ensembl: ENSG00000005381
• Gene ID: 4353
• mRNA Refseq: NM_000250
• Protein Refseq: NP_000241
• MIM: 606989
• UniProt ID: P05164
• Chromosome Location: 17q23.1
• Function: calcium ion binding; chromatin binding; heme binding; oxidoreductase activity; peroxidase activity

Reviews

08/12/2022

The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.

05/05/2022

The MPO proteins purchased from your company is suitable for WB.

01/03/2021

Big company with guaranteed after-sales service., customers buy with confidence.

Q&As

Where is the MPO synthesized?

MPO is synthesized and stored by granulocytes in the bone marrow.

What biological processes are MPO involved in?

MPO mediates the production of halogenated oxidants in phagosomes and plays a key role in bacterial killing and protecting the body from disease.

What is the relationship of MPO to hypochlorous acid?

Under physiological conditions in the body, MPO catalyzes the production of hypochlorous acid.

What diseases can MPO be used as a marker for?

MPO can be used as a marker for cerebral stroke.

What diseases is MPO relevant to research?

MPO has been associated with studies of diseases such as leukemia and coronary heart disease.