Recombinant Human MYH7 Protein (Arg1268-Leu1516), His tagged

• Cat.No.: MYH7-2387H
• Product Overview: Recombinant human MYH7 (Arg1268-Leu1516) protein fused with His tag was expressed in E. coli.

Specification

• Description: Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing distal myopathy.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 30.59 kDa
• Protein Length: Arg1268-Leu1516
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: MYH7 myosin heavy chain 7 [ Homo sapiens (human) ]
• Official Symbol: MYH7
• Synonyms: MYH7; myosin heavy chain 7; myosin-7; cardiac muscle myosin heavy chain 7 beta; myHC-beta; myhc-slow; myosin 7; myosin heavy chain beta-subunit; myosin, heavy chain 7, cardiac muscle, beta; myosin, heavy polypeptide 7, cardiac muscle, beta; rhabdomyosarcoma antigen MU-RMS-40.7A; CMH1; MPD1; SPMD; SPMM; CMD1S; MYHCB; CMYP7A; CMYP7B
• Gene ID: 4625
• mRNA Refseq: NM_000257
• Protein Refseq: NP_000248
• MIM: 160760
• UniProt ID: P12883