Recombinant Human N-myc Downstream Regulated 1, T7-tagged

• Cat.No.: NDRG1-2947H
• Product Overview: Recombinant Human NDRG1 was produced inE.coliwith a T7 tag at N-terminus. MW = 42863 Da (1-394 aa).

Specification

• Cat. No.: NDRG1-2947H
• Description: N-myc downstream regulated gene (NDRG)-1 is one of 4 members of the NDRG α/β-hydrolase family. This protein is classified in databases as a tumor suppressor and heavy metal-response protein. Its functions include cell-cycle regulation, cellular differentiation, apoptosis, hypoxia response and metal-ion sensing. Mutation in the NDRG1 gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom (HMSNL), a severe autosomal recessive form of Charcot-Marie-Tooth (CMT) disease.
• Source: E.coli.
• Form: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT.
• Purity: 95%.
• Applications: MS. SDS.

Gene Information

• Gene Name: NDRG1 N-myc downstream regulated 1 [ Homo sapiens ]
• Synonyms: NDRG1; N-myc downstream regulated 1; GC4; RTP; DRG1; NDR1; NMSL; TDD5; CAP43; CMT4D; HMSNL; RIT42; TARG1; PROXY1; protein regulated by oxygen-1; tunicamycin-responsive protein; differentiation-related gene 1 protein; nickel-specific induction protein Cap43; reducing agents and tunicamycin-responsive protein; DRG-1; DRG1; Protein NDRG1; N-myc downstream-regulated gene 1 protein; Rit42
• Gene ID: 10397
• mRNA Refseq: NM_001135242
• Protein Refseq: NP_001128714
• MIM: 605262
• UniProt ID: Q92597
• Chromosome Location: 8q24
• Function: protein binding

Reviews

11/22/2020

Their expertise and assistance have been invaluable in troubleshooting and providing insightful solutions, greatly enhancing the progress of my experiments.

08/26/2020

They have proven to be a timely and reliable resource, readily addressing any concerns or challenges that arise during my research.

06/05/2018

The NDRG1 Protein's superior stability and functional performance render it an indispensable tool for a wide range of scientific investigations.

Q&As

Can NDRG1 be targeted for personalized medicine approaches?

Yes, understanding the individual's NDRG1 expression profile may enable personalized treatment strategies, especially in cancer therapy.

Are there therapeutic implications for modulating NDRG1 expression in cancer treatment?

Are there therapeutic implications for modulating NDRG1 expression in cancer treatment?

Are there clinical trials investigating the use of NDRG1-related therapies?

Yes, there are ongoing clinical trials exploring the safety and efficacy of NDRG1-targeted therapies in various diseases, reflecting the growing interest in its clinical applications.

How does NDRG1 contribute to cellular stress response?

NDRG1 is involved in cellular responses to various stresses, including oxidative stress and DNA damage, playing a role in maintaining cellular homeostasis.

How does NDRG1 affect cardiovascular health?

NDRG1 is involved in processes related to cardiac hypertrophy and response to ischemic stress, making it relevant to cardiovascular diseases.