| Description : |
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
111.7 kDa |
| AA Sequence : |
MMSFGGADALLGAPFAPLHGGGSLH YALARKGGAGGTRSAAGSSSGFHSW TRTSVSSVSASPSRFRGAGAASSTD SLDTLSNGPEGCMVAVATSRSEKEQ LQALNDRFAGYIDKVRQLEAHNRSL EGEAAALRQQQAGRSAMGELYEREV REMRGAVLRLGAARGQLRLEQEHLL EDIAHVRQRLDDEARQREEAEAAAR ALARFAQEAEAARVDLQKKAQALQE ECGYLRRXHQEEVGELLGQIQGSGA AQAQMQAETRDALKCDVTSALREIR AQLEGHAVQSTLQSEEWFRVRLDRL SEAAKVNTDAMRSAQEEITEYRRQL QARTTELEALKSTKDSLERQRSELE DRHQADIASYQEAIQQLDAELRNTK WEMAAQLREYQDLLNVKMALDIEIA AYRKLLEGEECRIGFGPIPFSLPEG LPKIPSVSTHIKVKSEEKIKVVEKS EKETVIVEEQTEETQVTEEVTEEEE KEAKEEEGKEEEGGEEEEAEGGEEE TKSPPAEEAASPEKEAKSPVKEEAK SPAEAKSPEKEEAKSPAEVKSPEKA KSPAKEEAKSPPEAKSPEKEEAKSP AEVKSPEKAKSPAKEEAKSPAEAKS PEKAKSPVKEEAKSLAEAKSPVKEE AKSPAEVKSPEKAKSPTKEEAKSPE KAKSPEKEEAKSPEKAKSPVKAEAK SPEKAKSPVKAEAKSPEKAKSPVKE EAKSPEKAKSPVKEEAKSPEKAKSP VKEEAKTPEKAKSPVKEEAKSPEKA KSPEKAKTLDVKSPEAKTPAKEEAR SPADKFPEKAKSPVKEEVKSPEKAK SPLKEDAKAPEKEIPKKEEVKSPVK EEEKPQEVKVKEPPKKAEEEKAPAT PKTEEKKDSKKEEAPKKEAPKPKVE EKKEPAVEKPKESKVEAKKEEAEDK KKVPTPEKEAPAKVEVKEDAKPKEK TEVAKKEPDDAKAKEPSKPAEKKEA APEKKDTKEEKAKKPEEKPKTEAKA KEDDKTLSKEPSKPKAEKAEKSSST DQKDSKPPEKATEDKAAKGKTRTRP LEQKLISEEDLAANDILDYKDDDDK V |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
