Recombinant Human NEU1, His-tagged
Cat.No. : | NEU1-156H |
Product Overview : | Recombinant Human Sialidase-1 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Glu48-Leu415) of Human NEU1 fused with a 6His tag at the C-terminus. |
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Description : | Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues; it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme Sialidase-1 leads to sialidosis, a rare lysosomal storage disease. Sialidase-1 has been shown to interact with Cathepsin A (protective protein), β-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
AA Sequence : | ENDFGLVQPLVTMEQLLWVSGRQIG SVDTFRIPLITATPRGTLLAFAEAR KMSSSDEGAKFIALR RSMDQGSTWSPTAFIVNDGDVPDGL NLGAVVSDVETGVVFLFYSLCAHKA GCQVASTMLVWSKDD GVSWSTPRNLSLDIGTEVFAPGPGS GIQKQREPRKGRLIVCGHGTLERDG VFCLLSDDHGASWRY GSGVSGIPYGQPKQENDFNPDECQP YELPDGSVVINARNQNNYHCHCRIV LRSYDACDTLRPRDV TFDPELVDPVVAAGAVVTSSGIVFF SNPAHPEFRVNLTLRWSFSNGTSWR KETVQLWPGPSGYSS LATLEGSMDGEEQAPQLYVLYEKGR NHYTESISVAKISVYGTLVDHHHHH H |
Endotoxin : | Less than 0.1 ng/μg (1 IEU/μg). |
Purity : | Greater than 95% as determined by reducing SDS-PAGE. |
Publication : |
Neuraminidases 1 and 3 Trigger Atherosclerosis by Desialylating Low‐Density Lipoproteins and Increasing Their Uptake by Macrophages (2021)
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Gene Name : | NEU1 sialidase 1 (lysosomal sialidase) [ Homo sapiens ] |
Official Symbol : | NEU1 |
Synonyms : | NEU1; sialidase 1 (lysosomal sialidase); NEU; sialidase-1; G9 sialidase; exo-alpha-sialidase; lysosomal sialidase; acetylneuraminyl hydrolase; N-acetyl-alpha-neuraminidase 1; NANH; SIAL1; FLJ93471; |
Gene ID : | 4758 |
mRNA Refseq : | NM_000434 |
Protein Refseq : | NP_000425 |
MIM : | 608272 |
UniProt ID : | Q99519 |
Chromosome Location : | 6p21 |
Pathway : | Glycosphingolipid metabolism, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Other glycan degradation, organism-specific biosystem; Other glycan degradation, conserved biosystem; |
Function : | exo-alpha-(2->3)-sialidase activity; exo-alpha-(2->6)-sialidase activity; exo-alpha-(2->8)-sialidase activity; exo-alpha-sialidase activity; hydrolase activity, acting on glycosyl bonds; |
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NEU1-6018M | Recombinant Mouse NEU1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Neu1-4378M | Recombinant Mouse Neu1 Protein, Myc/DDK-tagged | +Inquiry |
NEU1-323H | Recombinant Human NEU1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
NEU1-3871HCL | Recombinant Human NEU1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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