Recombinant Human NGFR protein(Met1-Asn250), His-tagged

• Cat.No.: NGFR-6993H
• Product Overview: Recombinant Human NGFR (P08138) (Met 1-Asn 250) was expressed in HEK293, fused with a polyhistidine tag at the C-terminus.

Specification

• Source: HEK293
• Species: Human
• Tag: C-His
• Protein length: Met1-Asn250
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The secreted recombinant human NGFR consists of 233 amino acids and has a predicted molecular mass of 25 kDa. The apparent molecular mass of rhNGFR is approximately 45-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: NGFR nerve growth factor receptor [ Homo sapiens ]
• Official Symbol: NGFR
• Synonyms: NGFR; nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16); tumor necrosis factor receptor superfamily member 16; CD271; low affinity nerve growth factor receptor; p75NTR; TNFR superfamily; member 16; TNFRSF16; p75 ICD; NGF receptor; TNFR superfamily, member 16; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; p75(NTR); Gp80-LNGFR
• Gene ID: 4804
• mRNA Refseq: NM_002507
• Protein Refseq: NP_002498
• MIM: 162010
• UniProt ID: P08138

Reviews

06/22/2022

Its usage in ELISA and protein electron microscopy structure analysis has been reported to yield highly reproducible and interpretable results, providing valuable insights into the molecular mechanisms and biological processes under investigation.

09/02/2020

Its excellent performance in ELISA assays makes it a valuable tool in quantifying analytes in biological samples.

11/29/2018

Its reliability, specificity, and versatility make it an invaluable asset in studying and understanding complex biological systems.

Q&As

How is NGFR protein involved in neurodegenerative diseases?

NGFR protein is involved in the survival and maintenance of nerve cells, and its dysregulation has been associated with neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

Can NGFR protein be targeted for the treatment of neuropathic pain?

Research into NGFR protein as a potential target for the development of novel pain therapies is ongoing, with the aim of modulating pain signaling pathways.

Are there any therapeutic applications of NGFR protein in neurodegenerative diseases?

Some studies have explored the potential of NGFR protein as a therapeutic target for neurodegenerative diseases, with the aim of promoting nerve cell survival and function.

Can NGFR protein be used as a biomarker for neurodegenerative diseases?

Research suggests that alterations in NGFR protein levels may serve as a potential biomarker for neurodegenerative diseases, aiding in early diagnosis and monitoring disease progression.

How is NGFR protein being studied in the context of nerve regeneration?

NGFR protein is being investigated for its potential role in promoting nerve regeneration after injury, with the aim of developing new treatments for nerve damage and paralysis.