Recombinant Human NIPBL, GST-tagged
Cat.No. : | NIPBL-1296H |
Product Overview : | Recombinant Human NIPBL protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 2523-2686aa |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | NIPBL Nipped-B homolog (Drosophila) [ Homo sapiens ] |
Official Symbol : | NIPBL |
Synonyms : | NIPBL; Nipped-B homolog (Drosophila); nipped-B-like protein; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; IDN3; Scc2; sister chromatid cohesion 2 homolog (yeast); delangin; SCC2 homolog; sister chromatid cohesion 2 homolog; CDLS; CDLS1; IDN3-B; FLJ44854; |
Gene ID : | 25836 |
mRNA Refseq : | NM_015384 |
Protein Refseq : | NP_056199 |
MIM : | 608667 |
UniProt ID : | Q6KC79 |
Chromosome Location : | 5p13.2 |
Function : | chromo shadow domain binding; histone deacetylase binding; protein C-terminus binding; protein N-terminus binding; protein binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionNIPBL mutations may cause chromosomal structural abnormalities and gene expression regulation defects, thereby affecting the expression patterns of multiple genes, resulting in the onset of CdLS patients.
Mutations in the NIPBL protein may lead to abnormalities in gene expression regulation and chromosomal structure, which in turn affect embryonic development and cell function, resulting in the occurrence of CdLS.
Current studies have found limited associations between NIPBL protein and other diseases or pathological processes, mainly related to CdLS.
Abnormalities in the NIPBL protein may affect the development of multiple systems, including facial features, intellectual development, cardiovascular system, etc.
NIPBL protein plays an important role in the regulation of chromosome topology and gene expression. It is involved in the formation of DNA ligation and mimicry structures, as well as the regulation of chromosome accessibility and gene transcription.
Different types of NIPBL protein mutations may result in different clinical phenotypes of CdLS and are correlated with the severity of the patient's clinical presentation.
Customer Reviews (3)
Write a reviewShort half-life and high clearance of NIPBL allow them to penetrate the tissue and reach the lesion site, improving the therapeutic effect.
Due to purity and bioactivity of the NIPBL's production process make it a valuable research tool.
The biological activity is high and the experimental effect is very good.
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