| Description : |
This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
120.3 kDa |
| AA Sequence : |
MVSSAQMGFNLQALLEQLSQDELSK FKYLITTFSLAHELQKIPHKEVDKA DGKQLVEILTTHCDSYWVEMASLQV FEKMHRMDLSERAKDEVREAALKSF NKRKPLSLGITRKERPPLDVDEMLE RFKTEAQAFTETKGNVICLGKEVFK GKKPDKDNRCRYILKTKFREMWKSW PGDSKEVQVMAERYKMLIPFSNPRV LPGPFSYTVVLYGPAGLGKTTLAQK LMLDWAEDNLIHKFKYAFYLSCREL SRLGPCSFAELVFRDWPELQDDIPH ILAQARKILFVIDGFDELGAAPGAL IEDICGDWEKKKPVPVLLGSLLNRV MLPKAALLVTTRPRALRDLRILAEE PIYIRVEGFLEEDRRAYFLRHFGDE DQAMRAFELMRSNAALFQLGSAPAV CWIVCTTLKLQMEKGEDPVPTCLTR TGLFLRFLCSRFPQGAQLRGALRTL SLLAAQGLWAQTSVLHREDLERLGV QESDLRLFLDGDILRQDRVSKGCYS FIHLSFQQFLTALFYTLEKEEEEDR DGHTWDIGDVQKLLSGVERLRNPDL IQAGYYSFGLANEKRAKELEATFGC RMSPDIKQELLRCDISCKGGHSTVT DLQELLGCLYESQEEELVKEVMAQF KEISLHLNAVDVVPSSFCVKHCRNL QKMSLQVIKENLPENVTASESDAEV ERSQDDQHMLPFWTDLCSIFGSNKD LMGLAINDSFLSASLVRILCEQIAS DTCHLQRVVFKNISPADAHRNLCLA LRGHKTVTYLTLQGNDQDDMFPALC EVLRHPECNLRYLGLVSCSATTQQW ADLSLALEVNQSLTCVNLSDNELLD EGAKLLYTTLRHPKCFLQRLSLENC HLTEANCKDLAAVLVVSRELTHLCL AKNPIGNTGVKFLCEGLRYPECKLQ TLVLWNCDITSDGCCDLTKLLQEKS SLLCLDLGLNHIGVKGMKFLCEALR KPLCNLRCLWLWGCSIPPFSCEDLC SALSCNQSLVTLDLGQNPLGSSGVK MLFETLTCSSGTLRTLRLKIDDFND ELNKLLEEIEEKNPQLIIDTEKHHP WAERPSSHDFMITRTRPLEQKLISE EDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
