Recombinant Human NOTUM Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: NOTUM-1624H
• Product Overview: NOTUM MS Standard C13 and N15-labeled recombinant protein (NP_848588) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: NOTUM (Notum, Palmitoleoyl-Protein Carboxylesterase) is a Protein Coding gene. Diseases associated with NOTUM include Scalp-Ear-Nipple Syndrome and Suppurative Periapical Periodontitis. Among its related pathways are Signaling by GPCR and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include hydrolase activity and palmitoleyl hydrolase activity.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 48.6 kDa
• AA Sequence: MAQVKSLAQSLYPCSAQQLNEDLRL HLLLNTSVTCNDGSPAGYYLKESRG SRRWLLFLEGGWYCFNRENCDSRYD TMRRLMSSRDWPRTRTGTGILSSQP EENPYWWNANMVFIPYCSSDVWSGA SSKSEKNEYAFMGALIIQEVVRELL GRGLSGAKVLLLAGSSAGGTGVLLN VDRVAEQLEKLGYPAIQVRGLADSG WFLDNKQYRHTDCVDTITCAPTEAI RRGIRYWNGVVPERCRRQFQEGEEW NCFFGYKVYPTLRCPVFVVQWLFDE AQLTVDNVHLTGQPVQEGLRLYIQN LGRELRHTLKDVPASFAPACLSHEI IIRSHWTDVQVKGTSLPRALHCWDR SLHDSHKASKTPLKGCPVHLVDSCP WPHCNPSCPTVRDQFTGQEMNVAQF LMHMGFDMQTVAQPQGLEPSELLGM LSNGSTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: NOTUM notum, palmitoleoyl-protein carboxylesterase [ Homo sapiens (human) ]
• Official Symbol: NOTUM
• Synonyms: NOTUM; notum pectinacetylesterase homolog (Drosophila); protein notum homolog
• Gene ID: 147111
• mRNA Refseq: NM_178493
• Protein Refseq: NP_848588
• MIM: 609847
• UniProt ID: Q6P988

Reviews

08/26/2021

Its excellent performance in ELISA assays makes it a valuable tool in quantifying analytes in biological samples.

11/09/2020

Its reliability, specificity, and versatility make it an invaluable asset in studying and understanding complex biological systems.

07/20/2020

Its usage in ELISA and protein electron microscopy structure analysis has been reported to yield highly reproducible and interpretable results, providing valuable insights into the molecular mechanisms and biological processes under investigation.

Q&As

In neurological disorders, how does NOTUM protein contribute to therapeutic interventions?

NOTUM's role in Wnt signaling modulation has implications for neurodegenerative disorders, and targeting NOTUM may offer therapeutic avenues for conditions such as Alzheimer's disease.

How does NOTUM protein affect stem cell function?

NOTUM is involved in the regulation of stem cell behavior through its influence on Wnt signaling, making it a target for manipulating stem cell activities.

Are there any ongoing clinical trials exploring NOTUM-targeted therapies?

Several clinical trials are underway to investigate the safety and efficacy of NOTUM inhibitors in cancer patients, providing valuable insights into their clinical potential.

How does NOTUM protein influence tissue homeostasis?

NOTUM's role in regulating Wnt signaling contributes to tissue homeostasis, and understanding this mechanism can provide insights into maintaining tissue health.

How can NOTUM protein be utilized in personalized medicine approaches?

Understanding individual variations in NOTUM expression and activity may allow for personalized treatment strategies, tailoring interventions based on a patient's molecular profile.