| Description : |
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms. The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2). Also see NPR3, which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively). |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
119 kDa |
| AA Sequence : |
MPGPRRPAGSRLRLLLLLLLPPLLL LLRGSHAGNLTVAVVLPLANTSYPW SWARVGPAVELALAQVKARPDLLPG WTVRTVLGSSENALGVCSDTAAPLA AVDLKWEHNPAVFLGPGCVYAAAPV GRFTAHWRVPLLTAGAPALGFGVKD EYALTTRAGPSYAKLGDFVAALHRR LGWERQALMLYAYRPGDEEHCFFLV EGLFMRVRDRLNITVDHLEFAEDDL SHYTRLLRTMPRKGRVIYICSSPDA FRTLMLLALEAGLCGEDYVFFHLDI FGQSLQGGQGPAPRRPWERGDGQDV SARQAFQAAKIITYKDPDNPEYLEF LKQLKHLAYEQFNFTMEDVLVNTIP ASFHDGLLLYIQAVTETLAHGGTVT DGENITQRMWNRSFQGVTGYLKIDS SGDRETDFSLWDMDPENGAFRVVLN YNGTSQELVAVSGRKLNWPLGYPPP DIPKCGFDNEDPACNQDHLSTLEVL ALVGSLSLLGILIVSFFIYRKMQLE KELASELWRVRWEDVEPSSLERHLR SAGSRLTLSGRGSNYGSLLTTEGQF QVFAKTAYYKGNLVAVKRVNRKRIE LTRKVLFELKHMRDVQNEHLTRFVG ACTDPPNICILTEYCPRGSLQDILE NESITLDWMFRYSLTNDIVKGMLFL HNGAICSHGNLKSSNCVVDGRFVLK ITDYGLESFRDLDPEQGHTVYAKKL WTAPELLRMASPPVRGSQAGDVYSF GIILQEIALRSGVFHVEGLDLSPKE IIERVTRGEQPPFRPSLALQSHLEE LGLLMQRCWAEDPQERPPFQQIRLT LRKFNRENSSNILDNLLSRMEQYAN NLEELVEERTQAYLEEKRKAEALLY QILPHSVAEQLKRGETVQAEAFDSV TIYFSDIVGFTALSAESTPMQVVTL LNDLYTCFDAVIDNFDVYKVETIGD AYMVVSGLPVRNGRLHACEVARMAL ALLDAVRSFRIRHRPQEQLRLRIGI HTGPVCAGVVGLKMPRYCLFGDTVN TASRMESNGEALKIHLSSETKAVLE EFGGFELELRGDVEMKGKGKVRTYW LLGERGSSTRGTRTRPLEQKLISEE DLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
