Recombinant Human NTRK3, Fc Chimera
Cat.No. : | NTRK3-110H |
Product Overview : | Recombinant Human tyrosine kinase receptor C was fused to the Fc region of human IgG1 (aa 93-330). The chimeric protein was expressed in modifiedhuman 293 cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | NTRK3-110H |
Description : | TrkC, also known as neurotrophic tyrosine kinase receptor type 3 (NTRK3), is a member of the tropomyosin-related kinase (trk or Trk) receptor family, consisting of TrkA, TrkB, and TrkC. Trk receptors bind neurotrophins, including neural growth factor (NGF), brain derived neurotrophic factor (BDNF), and neurotrophic factors 3 and 4/5 (NT-3, NT4/5). TrkC is located on the plasma membrane of neural cells such as the hippocampus, the cerebral cortex, and the granular cell layer of the cerebellum, and it specifically binds NT-3 as a ligand. TrkC is a heavily glycosylated molecule with 13 potential N-linked glycosylation sites within the extracellular domain (ECD). |
Source : | human 293 cells. |
Molecular Mass : | TrkC - Fc Chimera migrates as a broad band between 85 and 150 kDa in SDS-PAGE due to post-translational modifications, in particular glycosylation. This compares with the unmodified TrkC – Fc Chimera that has a predicted molecular mass of 71.9 kDa. |
PI : | TrkC – Fc Chimera separates into a number of isoforms with a pI between 4 and 7 in 2D PAGE due to post-translational modifications, in particular glycosylation. This compares with the unmodified TrkC – Fc Chimera that has a predicted pI of 5.8. |
% Carbohydrate : | TrkC – Fc Chimera consists of 15-55% carbohydrate by weight. |
Glycosylation : | TrkC – Fc Chimera is N-glycosylated and is probably O-glycosylated. |
Purity : | >95%, as determined by SDS-PAGE and visualized by silver stain. |
Formulation : | When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose. |
Reconstitution : | It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. |
Storage : | Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. |
Gene Name : | NTRK3 neurotrophic tyrosine kinase, receptor, type 3 [ Homo sapiens ] |
Synonyms : | neurotrophic tyrosine kinase, receptor, type 3; TRKC; gp145(trkC); NTRK3; ETV6-NTRK3 fusion; OTTHUMP00000192915; neurotrophin 3 receptor; tyrosine kinase receptor C; NT-3 growth factor receptor; ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; EC 2.7.10.1; GP145-TrkC; OTTHUMP00000192915; Trk-C; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase |
Gene ID : | 4916 |
mRNA Refseq : | NM_001007156 |
Protein Refseq : | NP_001007157 |
MIM : | 191316 |
UniProt ID : | Q16288 |
Chromosome Location : | 15q25 |
Pathway : | Neurotrophin signaling pathway |
Function : | ATP binding; neurotrophin receptor activity; nucleotide binding; protein binding; transferase activity; transmembrane receptor protein tyrosine kinase activity |
Products Types
◆ Recombinant Protein | ||
NTRK3-2938R | Recombinant Rhesus Macaque NTRK3 Protein, His (Fc)-Avi-tagged | +Inquiry |
NTRK3-3765R | Recombinant Rat NTRK3 Protein, His (Fc)-Avi-tagged | +Inquiry |
NTRK3-159H | Active Recombinant Human NTRK3 protein(Met1-Asp428), His&hFc-tagged | +Inquiry |
NTRK3-4468H | Recombinant Human NTRK3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ntrk3-009M | Recombinant Mouse Ntrk3 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
NTRK3-2825HCL | Recombinant Human NTRK3 cell lysate | +Inquiry |
NTRK3-2583MCL | Recombinant Mouse NTRK3 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1632 | U2OS TrkC Bioassay Kit | +Inquiry |
Kit-1633 | TrkC Functional Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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