Description : |
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
92.8 kDa |
AA Sequence : |
MDVSLCPAKCSFWRIFLLGSVWLDY VGSVLACPANCVCSKTEINCRRPDD GNLFPLLEGQDSGNSNGNASINITD ISRNITSIHIENWRSLHTLNAVDME LYTGLQKLTIKNSGLRSIQPRAFAK NPHLRYINLSSNRLTTLSWQLFQTL SLRELQLEQNFFNCSCDIRWMQLWQ EQGEAKLNSQNLYCINADGSQLPLF RMNISQCDLPEISVSHVNLTVREGD NAVITCNGSGSPLPDVDWIVTGLQS INTHQTNLNWTNVHAINLTLVNVTS EDNGFTLTCIAENVVGMSNASVALT VYYPPRVVSLEEPELRLEHCIEFVV RGNPPPTLHWLHNGQPLRESKIIHV EYYQEGEISEGCLLFNKPTHYNNGN YTLIAKNPLGTANQTINGHFLKEPF PESTDNFILFDEVSPTPPITVTHKP EEDTFGVSIAVGLAAFACVLLVVLF VMINKYGRRSKFGMKGPVAVISGEE DSASPLHHINHGITTPSSLDAGPDT VVIGMTRIPVIENPQYFRQGHNCHK PDTYVQHIKRRDIVLKRELGEGAFG KVFLAECYNLSPTKDKMLVAVKALK DPTLAARKDFQREAELLTNLQHEHI VKFYGVCGDGDPLIMVFEYMKHGDL NKFLRAHGPDAMILVDGQPRQAKGE LGLSQMLHIASQIASGMVYLASQHF VHRDLATRNCLVGANLLVKIGDFGM SRDVYSTDYYRVGGHTMLPIRWMPP ESIMYRKFTTESDVWSFGVILWEIF TYGKQPWFQLSNTEVIECITQGRVL ERPRVCPKEVYDVMLGCWQREPQQR LNIKEIYKILHALGKATPIYLDILG TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |