Recombinant Human NUMB1 Mutant (R262W) Protein, Myc/DDK-tagged

• Cat.No.: NUMB-056H
• Product Overview: Purified mutant recombinant protein of Human numb homolog (Drosophila) (NUMB), transcript variant 1, mutation at(R262W) with a Myc/DDK tag was expressed in HEK293

Specification

• Description: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 70.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for at least 12 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: > 50 μg/mL as determined by microplate Bradford method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: NUMB NUMB endocytic adaptor protein [ Homo sapiens (human) ]
• Official Symbol: NUMB
• Synonyms: NUMB; NUMB endocytic adaptor protein; S171; C14orf41; c14_5527; protein numb homolog; h-Numb; numb homolog
• Gene ID: 8650
• mRNA Refseq: NM_001005743
• Protein Refseq: NP_001005743
• MIM: 603728
• UniProt ID: P49757