| Description : |
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
64.9 kDa |
| AA Sequence : |
MSRSAAASGGPRRPERHLPPAPCGA PGPPETCRTEPDGAGTMNKLRQSLR RRKPAYVPEASRPHQWQADEDAVRK GTCSFPVRYLGHVEVEESRGMHVCE DAVKKLKAMGRKSVKSVLWVSADGL RVVDDKTKDLLVDQTIEKVSFCAPD RNLDKAFSYICRDGTTRRWICHCFL ALKDSGERLSHAVGCAFAACLERKQ RREKECGVTAAFDASRTSFAREGSF RLSGGGRPAEREAPDKKKAEAAAAP TVAPGPAQPGHVSPTPATTSPGEKG EAGTPVAAGTTAAAIPRRHAPLEQL VRQGSFRGFPALSQKNSPFKRQLSL RLNELPSTLQRRTDFQVKGTVPEME PPGAGDSDSINALCTQISSSFASAG APAPGPPPATTGTSAWGEPSVPPAA AFQPGHKRTPSEAERWLEEVSQVAK AQQQQQQQQQQQQQQQQQQQQAASV APVPTMPPALQPFPAPVGPFDAAPA QVAVFLPPPHMQPPFVPAYPGLGYP PMPRVPVVGITPSQMVANAFCSAAQ LQPQPATLLGKAGAFPPPAIPSAPG SQARPRPNGAPWPPEPAPAPAPELD PFEAQWAALEGKATVEKPSNPFSGD LQKTFEIELTRTRPLEQKLISEEDL AANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
