| Description : |
This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked cognitive disability with cerebellar hypoplasia and distinctive facial dysmorhphism. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
91.5 kDa |
| AA Sequence : |
MGHPPLEFSDCYLDSPDFRERLKCY EQELERTNKFIKDVIKDGNALISAM RNYSSAVQKFSQTLQSFQFDFIGDT LTDDEINIAESFKEFAELLNEVENE RMMMVHNASDLLIKPLENFRKEQIG FTKERKKKFEKDGERFYSLLDRHLH LSSKKKESQLQEADLQVDKERHNFF ESSLDYVYQIQEVQESKKFNIVEPV LAFLHSLFISNSLTVELTQDFLPYK QQLQLSLQNTRNHFSSTREEMEELK KRMKEAPQTCKLPGQPTIEGYLYTQ EKWALGISWVKYYCQYEKETKTLTM TPMEQKPGAKQGPLDLTLKYCVRRK TESIDKRFCFDIETNERPGTITLQA LSEANRRLWMEAMDGKEPIYHSPIT KQQEMELNEVGFKFVRKCINIIETK GIKTEGLYRTVGSNIQVQKLLNAFF DPKCPGDVDFHNSDWDIKTITSSLK FYLRNLSEPVMTYRLHKELVSAAKS DNLDYRLGAIHSLVYKLPEKNREML ELLIRHLVNVCEHSKENLMTPSNMG VIFGPTLMRAQEDTVAAMMNIKFQN IVVEILIEHFGKIYLGPPEESAAPP VPPPRVTARRHKPITISKRLLRERT VFYTSSLDESEDEIQHQTPNGTITS SIEPPKPPQHPKLPIQRSGETDPGR KSPSRPILDGKLEPCPEVDVGKLVS RLQDGGTKITPKATNGPMPGSGPTK TPSFHIKRPAPRPLAHHKEGDADSF SKVRPPGEKPTIIRPPVRPPDPPCR AATPQKPEPKPDIVAGNAGEITSSV VASRTRFFETASRKTGSSQGRLPGD ESTRTRPLEQKLISEEDLAANDILD YKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
