Recombinant Human ORC6 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ORC6-3522H
• Product Overview: ORC6L MS Standard C13 and N15-labeled recombinant protein (NP_055136) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 28.1 kDa
• AA Sequence: MGSELIGRLAPRLGLAEPDMLRKAE EYLRLSRVKCVGLSARTTETSSAVM CLDLAASWMKCPLDRAYLIKLSGLN KETYQSCLKSFECLLGLNSNIGIRD LAVQFSCIEAVNMASKILKSYESSL PQTQQVDLDLSRPLFTSAALLSACK ILKLKVDKNKMVATSGVKKAIFDRL CKQLEKIGQQVDREPGDVATPPRKR KKIVVEAPAKEMEKVEEMPHKPQKD EDLTQDYEEWKRKILENAASAQKAT AETRTRPLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ORC6 origin recognition complex subunit 6 [ Homo sapiens (human) ]
• Official Symbol: ORC6
• Synonyms: ORC6; origin recognition complex, subunit 6; ORC6L, origin recognition complex, subunit 6 homolog like (yeast), origin recognition complex, subunit 6 like (yeast); origin recognition complex subunit 6; ORC6L
• Gene ID: 23594
• mRNA Refseq: NM_014321
• Protein Refseq: NP_055136
• MIM: 607213
• UniProt ID: Q9Y5N6