| Description : |
This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
96.3 kDa |
| AA Sequence : |
MAGRVPSLLVLLVFPSSCLAFRSPL SVFKRFKETTRPFSNECLGTTRPVV PIDSSDFALDIRMPGVTPKQSDTYF CMSMRIPVDEEAFVIDFKPRASMDT VHHMLLFGCNMPSSTGSYWFCDEGT CTDKANILYAWARNAPPTRLPKGVG FRVGGETGSKYFVLQVHYGDISAFR DNNKDCSGVSLHLTRLPQPLIAGMY LMMSVDTVIPAGEKVVNSDISCHYK NYPMHVFAYRVHTHHLGKVVSGYRV RNGQWTLIGRQSPQLPQAFYPVGHP VDVSFGDLLAARCVFTGEGRTEATH IGGTSSDEMCNLYIMYYMEAKHAVS FMTCTQNVAPDMFRTIPPEANIPIP VKSDMVMMHEHHKETEYKDKIPLLQ QPKREEEEVLDQDFHMEEALDWPGV YLLPGQVSGVALDPKNNLVIFHRGD HVWDGNSFDSKFVYQQIGLGPIEED TILVIDPNNAAVLQSSGKNLFYLPH GLSIDKDGNYWVTDVALHQVFKLDP NNKEGPVLILGRSMQPGSDQNHFCQ PTDVAVDPGTGAIYVSDGYCNSRIV QFSPSGKFITQWGEESSGSSPLPGQ FTVPHSLALVPLLGQLCVADRENGR IQCFKTDTKEFVREIKHSSFGRNVF AISYIPGLLFAVNGKPHFGDQEPVQ GFVMNFSNGEIIDIFKPVRKHFDMP HDIVASEDGTVYIGDAHTNTVWKFT LTEKLEHRSVKKAGIEVQEIKEAEA VVETKMENKPTSSELQKMQEKQKLI KEPGSGVPVVLITTLLVIPVVVLLA IAIFIRWKKSRAFGDSEHKLETSSG RVLGRFRGKGSGGLNLGNFFASRKG YSRKGFDRLSTEGSDQEKEDDGSES EEEYSAPLPALAPSSSTRTRPLEQK LISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
