Description : |
This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
64.2 kDa |
AA Sequence : |
MLKLVGGGGGQDWACSVAGTSLGGE EAAFEVARPGDQGKAGGGSPGWGCA GIPDSAPGAGVLQAGAVGPARGGQG AEEVGESAGGGEERRVRHPQAPALR LLNRKPQGGSGEIKTPENDLQRGRL SRGPRTAPPAPGMGDRSGQQERSVP HSPGAPVGTSAAAVNGLLHNGFHPP PVQPPHVCSRGPVGGSDAAPQRLPL LPELQPQPLLPQHDSPAKKCRLRRR MDSGRKNRPPFPWFGMDIGGTLVKL VYFEPKDITAEEEQEEVENLKSIRK YLTSNTAYGKTGIRDVHLELKNLTM CGRKGNLHFIRFPSCAMHRFIQMGS EKNFSSLHTTLCATGGGAFKFEEDF RMIADLQLHKLDELDCLIQGLLYVD SVGFNGKPECYYFENPTNPELCQKK PYCLDNPYPMLLVNMGSGVSILAVY SKDNYKRVTGTSLGGGTFLGLCCLL TGCETFEEALEMAAKGDSTNVDKLV KDIYGGDYERFGLQGSAVASSFGNM MSKEKRDSISKEDLARATLVTITNN IGSIARMCALNENIDRVVFVGNFLR INMVSMKLLAYAMDFWSKGQLKALF LEHEGYFGAVGALLELFKMTDDKTR TRPLEQKLISEEDLAANDILDYKDD DDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |