| Description : |
This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
59.1 kDa |
| AA Sequence : |
MRRLGPFHPRVHWAAPPSLSSGLHR LLFLRGTRIPSSTTLSPPRHDSLSL DGGTVNPPRVREPTGREAFGPSPAS SDWLPARWRNGRGGRPRARLCSGWT AAEEARRNPTLGGLLGRQRLLLRMG GGRLGAPMERHGRASATSVSSAGEQ AAGDPEGRRQEPLRRRASSASVPAV GASAEGTRRDRLGSYSGPTSVSRQR VESLRKKRPLFPWFGLDIGGTLVKL VYFEPKDITAEEEEEEVESLKSIRK YLTSNVAYGSTGIRDVHLELKDLTL CGRKGNLHFIRFPTHDMPAFIQMGR DKNFSSLHTVFCATGGGAYKFEQDF LTIGDLQLCKLDELDCLIKGILYID SVGFNGRSQCYYFENPADSEKCQKL PFDLKNPYPLLLVNIGSGVSILAVY SKDNYKRVTGTSLGGGTFFGLCCLL TGCTTFEEALEMASRGDSTKVDKLV RDIYGGDYERFGLPGWAVASSFGNM MSKEKREAVSKEDLARATLITITNN IGSIARMCALNENINQVVFVGNFLR INTIAMRLLAYALDYWSKGQLKALF SEHEGYFGAVGALLELLKIPSGPTR TRRLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
