| Description : |
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
181.4 kDa |
| AA Sequence : |
MRLWSWVLHLGLLSAALGCGLAERP RRARRDPRAGRPPRPAAGPATCATR AARGRRASPPPPPPPGGAWEAVRVP RRRQQREARGATEEPSPPSRALYFS GRGEQLRLRADLELPRDAFTLQVWL RAEGGQRSPAVITGLYDKCSYISRD RGWVVGIHTISDQDNKDPRYFFSLK TDRARQVTTINAHRSYLPGQWVYLA ATYDGQFMKLYVNGAQVATSGEQVG GIFSPLTQKCKVLMLGGSALNHNYR GYIEHFSLWKVARTQREILSDMETH GAHTALPQLLLQENWDNVKHAWSPM KDGSSPKVEFSNAHGFLLDTSLEPP LCGQTLCDNTEVIASYNQLSSFRQP KVVRYRVVNLYEDDHKNPTVTREQV DFQHHQLAEAFKQYNISWELDVLEV SNSSLRRRLILANCDISKIGDENCD PECNHTLTGHDGGDCRHLRHPAFVK KQHNGVCDMDCNYERFNFDGGECCD PEITNVTQTCFDPDSPHRAYLDVNE LKNILKLDGSTHLNIFFAKSSEEEL AGVATWPWDKEALMHLGGIVLNPSF YGMPGHTHTMIHEIGHSLGLYHVFR GISEIQSCSDPCMETEPSFETGDLC NDTNPAPKHKSCGDPGPGNDTCGFH SFFNTPYNNFMSYADDDCTDSFTPN QVARMHCYLDLVYQGWQPSRKPAPV ALAPQVLGHTTDSVTLEWFPPIDGH FFERELGSACHLCLEGRILVQYASN ASSPMPCSPSGHWSPREAEGHPDVE QPCKSSVRTWSPNSAVNPHTVPPAC PEPQGCYLELEFLYPLVPESLTIWV TFVSTDWDSSGAVNDIKLLAVSGKN ISLGPQNVFCDVPLTIRLWDVGEEV YGIQIYTLDEHLEIDAAMLTSTADT PLCLQCKPLKYKVVRDPPLQMDVAS ILHLNRKFVDMDLNLGSVYQYWVIT ISGTEESEPSPAVTYIHGSGYCGDG IIQKDQGEQCDDMNKINGDGCSLFC RQEVSFNCIDEPSRCYFHDGDGVCE EFEQKTSIKDCGVYTPQGFLDQWAS NASVSHQDQQCPGWVIIGQPAASQV CRTKVIDLSEGISQHAWYPCTISYP YSQLAQTTFWLRAYFSQPMVAAAVI VHLVTDGTYYGDQKQETISVQLLDT KDQSHDLGLHVLSCRNNPLIIPVVH DLSQPFYHSQAVRVSFSSPLVAISG VALRSFDNFDPVTLSSCQRGETYSP AEQSCVHFACEKTDCPELAVENASL NCSSSDRYHGAQCTVSCRTGYVLQI RRDDELIKSQTGPSVTVTCTEGKWN KQVACEPVDCSIPDHHQVYAASFSC PEGTTFGSQCSFQCRHPAQLKGNNS LLTCMEDGLWSFPEALCELMCLAPP PVPNADLQTARCRENKHKVGSFCKY KCKPGYHVPGSSRKSKKRAFKTQCT QDGSWQEGACVPVTCDPPPPKFHGL YQCTNGFQFNSECRIKCEDSDASQG LGSNVIHCRKDGTWNGSFHVCQEMQ GQCSVPNELNSNLKLQCPDGYAIGS ECATSCLDHNSESIILPMNVTVRDI PHWLNPTRVERVVCTAGLKWYPHPA LIHCVKGCEPFMGDNYCDAINNRAF CNYDGGDCCTSTVKTKKVTPFPMSC DLQGDCACRDPQAQEHSRKDLRGYS HGSGPTRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
