Recombinant Human PARK7 (DJ-1), His-tagged
Cat.No. : | PARK7-230H |
Product Overview : | Recombinant human PARK7 (DJ-1) (19-end) was expressed in E. coli cells using an N-terminal His tag. |
- Specification
- Gene Information
- Related Products
Description : | PARK7 or parkinson protein 7 belongs to the peptidase C56 family of proteins which acts as a positive regulator of androgen receptor-dependent transcription. PARK7 also functions as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. PARK7 mutations that impair transcriptional co-activator function can render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of Parkinson disease. PARK7 is an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide through oxidation of cys106. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Molecular Mass : | ~22 kDa |
Purity : | >85% by densitometry |
Applications : | Western Blot |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.2 μg/μl |
Gene Name : | PARK7 parkinson protein 7 [ Homo sapiens ] |
Official Symbol : | PARK7 |
Synonyms : | PARK7; parkinson protein 7; Parkinson disease (autosomal recessive, early onset) 7; protein DJ-1; DJ 1; DJ1; oncogene DJ1; DJ-1; FLJ27376; FLJ34360; FLJ92274; |
Gene ID : | 11315 |
mRNA Refseq : | NM_001123377 |
Protein Refseq : | NP_001116849 |
MIM : | 602533 |
UniProt ID : | Q99497 |
Chromosome Location : | 1p36.23 |
Pathway : | Alpha-synuclein signaling, organism-specific biosystem; Parkinsons disease, organism-specific biosystem; |
Function : | mRNA binding; peptidase activity; peroxidase activity; peroxiredoxin activity; protein binding; protein homodimerization activity; |
Products Types
◆ Recombinant Protein | ||
PARK7-6498M | Recombinant Mouse PARK7 Protein, His (Fc)-Avi-tagged | +Inquiry |
Park7-1900M | Recombinant Mouse Park7 Protein, His-tagged | +Inquiry |
Park7-4676M | Recombinant Mouse Park7 Protein, Myc/DDK-tagged | +Inquiry |
PARK7-2549H | Recombinant Human PARK7 Protein, His-tagged | +Inquiry |
PARK7-3936R | Recombinant Rat PARK7 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
PARK7-3432HCL | Recombinant Human PARK7 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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