| Description : |
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
73.5 kDa |
| AA Sequence : |
MEIIRSNFKSNLHKVYQAIEEADFF AIDGEFSGISDGPSVSALTNGFDTP EERYQKLKKHSMDFLLFQFGLCTFK YDYTDSKYITKSFNFYVFPKPFNRS SPDVKFVCQSSSIDFLASQGFDFNK VFRNGIPYLNQEEERQLREQYDEKR SQANGAGALSYVSPNTSKCPVTIPE DQKKFIDQVVEKIEDLLQSEENKNL DLEPCTGFQRKLIYQTLSWKYPKGI HVETLETEKKERYIVISKVDEEERK RREQQKHAKEQEELNDAVGFSRVIH AIANSGKLVIGHNMLLDVMHTVHQF YCPLPADLSEFKEMTTCVFPRLLDT KLMASTQPFKDIINNTSLAELEKRL KETPFNPPKVESAEGFPSYDTASEQ LHEAGYDAYITGLCFISMANYLGSF LSPPKIHVSARSKLIEPFFNKLFLM RVMDIPYLNLEGPDLQPKRDHVLHV TFPKEWKTSDLYQLFSAFGNIQISW IDDTSAFVSLSQPEQVKIAVNTSKY AESYRIQTYAEYMGRKQEEKQIKRK WTEDSWKEADSKRLNPQCIPYTLQN HYYRNNSFTAPSTVGKRNLSPSQEE AGLEDGVSGEISDTELEQTDSCAEP LSEGRKKAKKLKRMKKELSPAGSIS KNSPATLFEVPDTWTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
