Recombinant Human PARP1 protein, His-tagged
Cat.No. : | PARP1-01H |
Product Overview : | Recombinant Human PARP1 protein(NP_001609.2), fused to His-tag, was expressed in E. coli. |
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Description : | This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | PBS, pH 7.0 |
Molecular Mass : | The protein has a calculated MW of 41.6 kDa. |
AA Sequence : | MNHKVHHHHHHHHHHMKSKLPKPVQ DLIKMIFDVESMKKAMVEYEIDLQK MPLGKLSKRQIQAAYSILSEVQQAV SQGSSDSQILDLSNRFYTLIPHDFG MKKPPLLNNADSVQAKAEMLDNLLD IEVAYSLLRGGSDDSSKDPIDVNYE KLKTDIKVVDRDSEEAEIIRKYVKN THATTHNAYDLEVIDIFKIEREGEC QRYKPFKQLHNRRLLWHGSRTTNFA GILSQGLRIAPPEAPVTGYMFGKGI YFADMVSKSANYCHTSQGDPIGLIL LGEVALGNMYELKHASHISKLPKGK HSVKGLGKTTPDPSANISLDGVDVP LGTGISSGVNDTSLLYNEYIVYDIA QVNLKYLLKLKFNFKTSLW |
Purity : | >= 95% by SDS-PAGE |
Storage : | Store it under sterile conditions at -20 to -80 ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Concentration : | 0.5 mg/ml |
Gene Name : | PARP1 poly(ADP-ribose) polymerase 1 [ Homo sapiens (human) ] |
Official Symbol : | PARP1 |
Synonyms : | PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1 |
Gene ID : | 142 |
mRNA Refseq : | NM_001618.4 |
Protein Refseq : | NP_001609.2 |
MIM : | 173870 |
UniProt ID : | P09874 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionYes, overactivation of the PARP1 protein can lead to apoptosis or necrosis of cells, which may be exploited in the treatment of certain diseases.
The PARP1 protein can repair DNA damage by attaching ADP-ribose groups to damaged DNA strands and recruiting other repair proteins.
In addition to PARP1's involvement in direct DNA repair, it can also modulate the selection of repair pathways and initiate other DNA damage sensing mechanisms.
Some studies have proposed that the interaction of PARP1 protein with DNA damage in tumor immunotherapy may affect the efficacy of immunotherapy.
Yes, the PARP1 protein is involved in the normal regulation of the cell cycle, especially G1/S and G2/M switching during DNA damage.
Overactivation of PARP1 depletes energy stores such as NAD+ and ATP and leads to apoptosis, or cell death.
Customer Reviews (3)
Write a reviewThis range of applications of PARP1 is breathtaking, and it can play an important role in any field.
This short half-life and high clearance of PARP1 make it have greater potential in the treatment of tumors, infections and other diseases, and it is expected to become a new generation of therapeutic drugs.
The purity and bioactivity of PARP1 make it a valuable resource for scientific research.
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