Recombinant Human PARP12, GST-tagged

• Cat.No.: PARP12-432H
• Product Overview: Recombinant Human PARP12, full length with N-terminal GST tag expressed in aBaculovirusinfected Sf9 cell expression system. MW = 106kDa.

Specification

• Cat. No.: PARP12-432H
• Description: Poly (ADP-ribose) polymerase (PARP) is a protein involved in a number of cellular processes involving mainly DNA repair and programmed cell death.
• Source: Sf9 cell.
• Purity: >50%.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT.
• Stability: >6 months at –80°C.

Gene Information

• Gene Name: PARP12 poly (ADP-ribose) polymerase family, member 12 [ Homo sapiens ]
• Synonyms: PARP12; poly (ADP-ribose) polymerase family, member 12; ZC3H1; MST109; MSTP109; ZC3HDC1; FLJ22693; poly ADP-ribose polymerase 12; zinc finger CCCH type domain containing 1; EC 2.4.2.30
• Gene ID: 64761
• mRNA Refseq: NM_022750
• Protein Refseq: NP_073587
• MIM: 612481
• UniProt ID: Q9H0J9
• Chromosome Location: 7q34
• Function: NAD+ ADP-ribosyltransferase activity; transferase activity; nucleic acid binding; zinc ion binding

Reviews

03/27/2023

The PARP12 protein comes highly recommended for a variety of research applications.

08/24/2020

Its exceptional performance in ELISA assays makes it a reliable tool for detecting and quantifying specific target molecules with high sensitivity and specificity.

07/28/2017

This level of support instills trust and confidence in the product, facilitating smooth and successful experimentation.

Q&As

Are there specific diseases where the clinical application of PARP12 is particularly relevant?

Yes, PARP12 has been implicated in the defense against various viral infections, making it relevant in the context of antiviral therapy.

How does PARP12 interact with other cellular components in the immune response?

PARP12 interacts with various proteins involved in the interferon pathway, influencing the immune response at multiple levels.

How does PARP12 contribute to the immune response?

PARP12 is involved in the modulation of interferon signaling pathways, enhancing the immune response against viral infections.

Can PARP12 be a potential target for therapeutic interventions?

Yes, targeting PARP12 may hold therapeutic potential, especially in the development of antiviral drugs.

In what ways does PARP12 contribute to antiviral activities?

PARP12 is known to inhibit viral replication and promote the degradation of viral RNA, contributing to the antiviral defense mechanism.