Recombinant Human PARP3 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PARP3-2607H
• Product Overview: PARP3 MS Standard C13 and N15-labeled recombinant protein (NP_005476) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 60.1 kDa
• AA Sequence: MAPKPKPWVQTEGPEKKKGRQAGRE EDPFRSTAEALKAIPAEKRIIRVDP TCPLSSNPGTQVYEDYNCTLNQTNI ENNNNKFYIIQLLQDSNRFFTCWNR WGRVGEVGQSKINHFTRLEDAKKDF EKKFREKTKNNWAERDHFVSHPGKY TLIEVQAEDEAQEAVVKVDRGPVRT VTKRVQPCSLDPATQKLITNIFSKE MFKNTMALMDLDVKKMPLGKLSKQQ IARGFEALEALEEALKGPTDGGQSL EELSSHFYTVIPHNFGHSQPPPINS PELLQAKKDMLLVLADIELAQALQA VSEQEKTVEEVPHPLDRDYQLLKCQ LQLLDSGAPEYKVIQTYLEQTGSNH RCPTLQHIWKVNQEGEEDRFQAHSK LGNRKLLWHGTNMAVVAAILTSGLR IMPHSGGRVGKGIYFASENSKSAGY VIGMKCGAHHVGYMFLGEVALGREH HINTDNPSLKSPPPGFDSVIARGHT EPDPTQDTELELDGQQVVVPQGQPV PCPEFSSSTFSQSEYLIYQESQCRL RYLLEVHLTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PARP3 poly(ADP-ribose) polymerase family member 3 [ Homo sapiens (human) ]
• Official Symbol: PARP3
• Synonyms: PARP3; poly (ADP-ribose) polymerase family, member 3; ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) like 3, ADPRTL3; poly [ADP-ribose] polymerase 3; ADPRT3; hPARP 3; IRT1; NAD+ ADP ribosyltransferase 3; pADPRT 3; poly(ADP ribose) polymerase 3; poly(ADP ribose) synthetase 3; ADPRT-3; poly[ADP-ribose] synthase 3; NAD+ ADP-ribosyltransferase 3; poly(ADP-ribose) synthetase-3; poly[ADP-ribose] synthetase 3; NAD(+) ADP-ribosyltransferase 3; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2; poly (ADP-ribose) polymerase)-like 3; ADPRTL2; ADPRTL3; PADPRT-3
• Gene ID: 10039
• mRNA Refseq: NM_005485
• Protein Refseq: NP_005476
• MIM: 607726
• UniProt ID: Q9Y6F1

Reviews

01/25/2023

An additional advantage of selecting the PARP3 protein is the outstanding technical support offered by its manufacturer.

09/09/2019

Their unwavering commitment to customer satisfaction assures me that any challenges or queries I may encounter will be expertly resolved.

01/13/2016

The combination of the protein's excellence and the manufacturer's exceptional technical support equips me with the necessary resources to overcome experimental obstacles and achieve groundbreaking results.

Q&As

How does PARP3 interact with other proteins in the DNA repair pathway?

PARP3 interacts with various proteins involved in DNA repair, forming complexes that coordinate the repair process.

How does the dysregulation of PARP3 relate to cancer development?

Dysregulation of PARP3 can lead to genomic instability and impaired DNA repair, contributing to the development and progression of certain cancers.

Are there any diagnostic tools specifically detecting PARP3 activity?

While there are research tools for studying PARP3 activity in the laboratory, clinical diagnostic tools targeting PARP3 are still in the early stages of development.

Is PARP3 involved in the regulation of immune responses?

Emerging research suggests that PARP3 may play a role in immune regulation, and its modulation could potentially impact immune responses in diseases such as cancer.

Are there any clinical trials involving PARP3 inhibitors?

Some clinical trials are exploring the efficacy and safety of PARP inhibitors, and their potential application in cancers where PARP3 is implicated.