Recombinant Human PAWR Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PAWR-459H
• Product Overview: PAWR MS Standard C13 and N15-labeled recombinant protein (NP_002574) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 36.6 kDa
• AA Sequence: MATGGYRTSSGLGGSTTDFLEEWKA KREKMRAKQNPPGPAPPGGGSSDAA GKPPAGALGTPAAAAANELNNNLPG GAPAAPAVPGPGGVNCAVGSAMLTR AAPGPRRSEDEPPAASASAAPPPQR DEEEPDGVPEKGKSSGPSARKGKGQ IEKRKLREKRRSTGVVNIPAAECLD EYEDDEAGQKERKREDAITQQNTIQ NEAVNLLDPGSSYLLQEPPRTVSGR YKSTTSVSEEDVSSRYSRTDRSGFP RYNRDANVSGTLVSSSTLEKKIEDL EKEVVRERQENLRLVRLMQDKEEMI GKLKEEIDLLNRDLDDIEDENEQLK QENKTLLKVVGQLTRTRTRPLEQKL ISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PAWR pro-apoptotic WT1 regulator [ Homo sapiens (human) ]
• Official Symbol: PAWR
• Synonyms: PAWR; PRKC, apoptosis, WT1, regulator; PRKC apoptosis WT1 regulator protein; par 4; PAR4; WT1-interacting protein; transcriptional repressor PAR4; prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; Par-4
• Gene ID: 5074
• mRNA Refseq: NM_002583
• Protein Refseq: NP_002574
• MIM: 601936
• UniProt ID: Q96IZ0