| Description : |
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. |
| Source : |
Wheat germ |
| Species : |
Human |
| Form : |
Liquid |
| Molecular Mass : |
87.7 kDa |
| AA Sequence : |
MENQGTRTQQIRQVLLLFVLLGMSQ AGSETWSFSVAEEMQSGSFVGNLAK DLGLKVRELSSRGARVVSNDKKQRL QLDINTGDLLLSETLDREELCGSIE PCVLHLQVLMQNPTQFLQIELQVRD INDHSPIFSEKQMLLEIPENSPVGA VFLLESAKDLDVGINAVKSYTISPN SHFHIKMRVIPDNRKYPELVLDKAL DYEELPELSFILSALDGGSPPRSGT ALVRVVVVDINDNSPEFEQAFYEVK IRENSILGSLILIVSAWDLDSGTNG EICYTFSHASEDIRKTFEINQKSGE ITLRAPLDFETIESYSIIIQATDGG GLFGKSTVIIHVIDVNDNAPEITVS SITSPIPENTPETVVMVFSIQDIDS GDNGRIVCSIPEDLPFVLKSSVENY YTLETERPLDRESTAEYNITITVTD LGIPRLKTEHNTTVLVSDVNDNAPT FTQTSYTLFVRENNSPALHIGSVSA TDRDSGTNAQVNYSLLPPQDLHLPL ASLVSINTDNGHLFALRSLDYEALQ AFDFRVGATDRGSPALSSEALVRVL VLDANDNSPFVLYPLQNGSAPCTEL VPRAAEPGYLVTKVVAVDGDSGQNA WLSYQLLKATEPGLFGVWAHNGEVR TARLLSERDAAKHRLVVLVKDNGEP PRSATATLQVLLVDGFSQPYLPLPE AAPAQAQADSLTVYLVVALASVSSL FLFSVLLFVAVRLCRRSRAASVGSC SVPKGPFPGHLVDVSGTGTLSQSYQ YEVCLTGGSETNEFKFLKPVIPNIQ AKGLGKNSEENSTFRNSFGFNF |
| Applications : |
Antibody Production; Functional Study; Compound Screening |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
